| Description |
1 online resource (viii, 291 pages) : illustrations (some color) |
| Series |
Progress in experimental tumor research ; v. 37 |
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Progress in experimental tumor research ; v. 37.
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| Summary |
Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists |
| Analysis |
Andre fag (naturvidenskab og teknik) Andre fag |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Cyclooxygenase 2 -- Inhibitors -- Therapeutic use
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Cancer -- Chemotherapy.
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Neoplasms -- drug therapy
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Cyclooxygenase Inhibitors -- therapeutic use
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Cancer -- Chemotherapy
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Chemotherapie.
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Krebs <Medizin> -- Prävention -- Prostaglandinsynthase -- Inhibitor -- Aufsatzsammlung.
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Prostaglandinsynthase -- Inhibitor -- Krebs <Medizin> -- Prävention -- Aufsatzsammlung.
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Inhibitor -- Prostaglandinsynthase -- Krebs <Medizin> -- Prävention -- Aufsatzsammlung.
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Krebs <Medizin> -- Therapie -- Prostaglandinsynthase -- Inhibitor -- Aufsatzsammlung.
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Prostaglandinsynthase -- Inhibitor -- Krebs <Medizin> -- Therapie -- Aufsatzsammlung.
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Inhibitor -- Prostaglandinsynthase -- Krebs <Medizin> -- Therapie -- Aufsatzsammlung.
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| Form |
Electronic book
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| Author |
Bertino, Joseph R
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| ISBN |
9783318009408 |
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3318009407 |
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