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Book Cover
Author Funahashi, S. (Shintaro)

Title Dorsolateral prefrontal cortex : working memory and executive functions / Shintaro Funahashi
Published Singapore : Springer, 2022


Description 1 online resource
Series Brain science
Brain science (Series)
Contents Intro -- Preface -- Acknowledgments -- Contents -- Chapter 1: Dorsolateral Prefrontal Cortex -- 1.1 Introduction -- 1.2 The Prefrontal Cortex -- 1.3 Features of the Prefrontal Cortex -- 1.4 Anatomical Features of the Prefrontal Cortex -- 1.4.1 Cytoarchitectonic Features -- 1.4.2 Cytoarchitectonic Features of the Lateral Prefrontal Cortex -- 1.4.3 Relations to the Thalamic Mediodorsal Nucleus -- 1.4.4 Granular Layer IV -- 1.4.5 Mesulamś Cortical Classification -- 1.5 Anatomical Features of the Lateral Prefrontal Cortex -- 1.5.1 Cellular Components -- Pyramidal Neurons Nonpyramidal Neurons -- Interactions Between Pyramidal and Nonpyramidal Neurons -- Modulation of Activity by Catecholamine and Monoamine -- 1.5.2 Anatomical Heterogeneity in Area 46 -- 1.5.3 Cortico-Cortical Connections -- Afferent Connections -- Efferent Connections -- Callosal Connections -- 1.5.4 Cortico-Subcortical Connections -- Anatomical Connections with the Thalamus -- Prefrontal Connections with the Basal Ganglia -- Prefrontal Connections with Other Subcortical Structures
1.5.5 Intracortical Structures: Columnar Organization -- 1.6 Functional Features of the Lateral Prefrontal Cortex -- 1.6.1 Human Prefrontal Functions -- 1.6.2 Functional Heterogeneity of the Prefrontal Cortex -- 1.6.3 Functional Heterogeneity in Human Prefrontal Cortex -- 1.6.4 Functional Development of the Prefrontal Cortex -- References -- Chapter 2: Historical Perspective of Prefrontal Research -- 2.1 Functional Localization of the Cerebral Cortex -- 2.2 Historical Perspective of Frontal Lobe Functions -- 2.2.1 Debate Between Holistic Theory and Localization Theory
2.2.2 Functions of the Frontal Lobe -- 2.2.3 Lashleyś Principles: Equipotentiality and Mass Action -- 2.2.4 The Prefrontal Cortex Has Some Specific Function -- 2.2.5 Jacobsenś Experiments Using Delayed-Response Task -- 2.2.6 Delayed-Response Deficits Caused by Prefrontal Lesions -- 2.2.7 Localization of the Cortical Area Responsible for Delayed-Response Performance -- 2.2.8 Delayed-Response Deficits Can Be Observed in Human Prefrontal Patients -- 2.2.9 Delayed-Response Deficits Can Also Be Observed in Rats and Dogs -- 2.3 Behavioral Deficits in Other Delay Tasks Caused by Prefrontal Lesions
2.3.1 Delayed Alternation Task and Importance of Spatial Factor -- 2.3.2 Delayed Matching-to-Sample Task and Other Delay Tasks -- 2.4 Cryogenic Depression of Prefrontal Functions -- 2.5 What Causes Delayed-Response Deficits? -- 2.5.1 Factors Affecting Delayed-Response Performances -- 2.5.2 Increased Susceptibility, Distractibility, and Hyperactivity to Irrelevant Stimuli -- 2.5.3 Kinesthetic Effects -- 2.6 Mnemonic Hypothesis of Prefrontal Function -- 2.6.1 Problems of Behavior Control During the Delay Period -- 2.6.2 An Oculomotor Version of the Delayed-Response Task
Summary The prefrontal cortex is known to play important roles for performing a variety of higher cognitive functions. Among regions of the prefrontal cortex, the dorsolateral prefrontal cortex plays the most important roles for these functions. This book focuses on functions of the dorsolateral prefrontal cortex, summarizes research results obtained mainly by non-human primate studies, and describes neural mechanisms of executive functions that the dorsolateral prefrontal cortex participates. First, to understand the feature of the dorsolateral prefrontal cortex and how its function has been understood, anatomical and functional features of the dorsolateral prefrontal cortex and historical overview of prefrontal functions are described. To understand functions of the prefrontal cortex and neural mechanisms of executive functions, working memory is an important concept and sustained activation during the memory period of working memory tasks is known as a neural mechanism of working memory. Therefore, this book describes features of sustained memory-related activity based on neurophysiological results obtained in the prefrontal cortex and how memory-related activity contributes to executive functions including control of attention, inhibitory control, task management, and planning. And further, this book describes how the dorsolateral prefrontal cortex contributes to neural mechanisms for sensory and motor processing, memory control in multi-task performance, decision-making, metacognition, and top-down control. Thus, this book provides important information regarding neural mechanisms of dorsolateral prefrontal functions to neuroscientists and helps to plan further investigation to understand prefrontal functions in primates and human subjects
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed January 5, 2023)
Subject Prefrontal cortex.
Executive functions (Neuropsychology)
Form Electronic book
ISBN 9789811972683