| Description |
1 online resource (xv, 317 pages) : illustrations, map |
| Series |
Methods in molecular medicine ; v. 3 |
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Methods in molecular medicine ; v. 3. 1543-1894
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| Contents |
Paradox of prion disease / Rosalind M. Ridley and Harry F. Baker -- Human spongiform encephalopathy : clinical presentation and diagnostic tests / Rajith de Silva -- Neuropathological diagnosis of human prion disease : morphological studies / James W. Ironside -- Neuropathological diagnosis of human prion disease : PrP immunocytochemical techniques / Jeanne E. Bell -- Diagnosis of bovine spongiform encephalopathy and scrapie by the detection of fibrils and the abnormal protein isoform / Michael J. Stack, Paula Keyes, and Anthony C. Scott |
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Exposure to, and inactivation of, the unconventional agents that cause transmissible degenerative encephalopathies / David M. Taylor -- Surveillance of prion disease in humans / Robert G. Will -- Environmental causes of human spongiform encephalopathy / Paul Brown -- Bovine spongiform encephalopathy : methods of analyzing the epidemic in the United Kingdom / John W. Wilesmith -- Handling the BSE epidemic in Great Britain / David A.J. Tyrrell and Kevin C. Taylor |
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Special problems of genetic counseling in adult-onset diseases : huntington's disease as a model / Jonathan R. Gray, Jo R. Soldan, and Peter S. Harper -- Genotyping and susceptibility of sheep to scrapie / Nora Hunter -- Strain typing studies of scrapie and BSE / Moira E. Bruce -- PrP-deficient mice in the study of transmissible spongiform encephalopathies / Jean C. Manson -- Transgenic approaches to prion "species-barrier" effects / David Westaway -- Methods for studying prion protein amyloid / Fabrizio Tagliavini [and others] |
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Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems / Byron Caughey [and others] -- Immunohistochemistry of resinated tissues for light and electron microscopy / Martin Jeffrey and Caroline M. Goodsir |
| Summary |
In Prion Diseases leading researchers and clinicians describe their state-of-the-art findings and hypotheses arising from a variety of different approaches to this group of diseases. Their approaches include clinical presentations, epidemiology, transgenic methods, and diagnostic tests via transmission electron microscopy and immunoblotting. The diseases covered include human and animal spongiform encephalopathies, such as Creutzfeldt-Jakob disease, mad cow disease, and scrapie. Prion Diseases illuminates the conflicting hypotheses that have evolved to explain these diverse disorders which can appear as infectious diseases a genetically determined diseases, as well as ones sharing neuropathological similarities with such common neurodegenerative diseases as Alzheimer's disease, Parkinson's disease, and amyotropic lateral sclerosis. It provides a much-needed overview of various approaches to understanding these diseases by showing how researchers have analyzed their different facets, ranging from the epidemiology of the human versions to molecular genetics of the animal forms of the diseases |
| Notes |
Source of title; title from title page |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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English |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Prion diseases.
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Prion Diseases
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Prions
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Prion diseases
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Prionen.
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Spongiforme encefalopathieën.
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Wetenschappelijke technieken.
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| Genre/Form |
Laboratory manuals.
|
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Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
Baker, Harry F.
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Ridley, Rosalind M.
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| ISBN |
0896033422 |
|
9780896033429 |
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9781592595877 |
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1592595871 |
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9781489940407 |
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1489940405 |
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9781489940391 |
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1489940391 |
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