Title Neurodegeneration and prion disease / edited by David R. Brown

Published New York, NY : Springer Science+Business Media, ©2005

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Description 1 online resource (xv, 473 pages) : illustrations Contents Preliminaries; Contents; 1. Introduction; 2. Neuropathology of transmissible spongiform encephalopathies (prion diseases); 3. Central pathogenesis of prion diseases; 4. Hereditary prion protein Amyloidoses; 5. Mouse behavioural studies and what they can teach us about prion diseases; 6. Electrophysiological approaches to the study of prion diseases; 7. Prion protein, prion protein-like protein, and neurodegeneration; 8. Oxidative stress and mitochondrial dysfunction in; 9. Mechanisms of prion toxicity and their relationship to prion infectivity 10. A stone guest on the brain: Death as a prion11. Molecular mechanisms mediating neuronal cell death in 11. Molecular mechanisms mediating neuronal cell death in; 12. Processing and mis-processing of the prion protein; 13. Signaling pathways controling prion neurotoxicity; 14. Cell culture models to unravel prion protein function and aberrancies in TSE; 15. Insights into the cellular trafficking of prion proteins; 16. The molecular basis of prion protein-mediated neuronal damage; 17. Conclusion: Intervention, the final frontier; Index Summary "This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow's disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state-of-the-art for other specialists and non-specialists in related fields."--Jacket Analysis biochemie biochemistry geneeskunde medicine neurologie neurology fysiologie physiology celbiologie cellular biology veeartsenijkunde veterinary medicine biomedische wetenschappen biomedicine neurowetenschap neuroscience Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Print version record In Springer e-books Subject Prion diseases. Nervous system -- Degeneration. Prion Diseases -- physiopathology Cell Death -- physiology Nerve Degeneration -- etiology Neurons -- physiology Prion Diseases -- complications Prions -- pathogenicity Prion Diseases HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia. MEDICAL -- Neurology. Medicine. Neurology. Neurosciences. Physiology -- Mathematics. Veterinary medicine. Biomedicine. Biochemistry, general. Molecular Medicine. Physiological, Cellular and Medical Topics. Biochemistry. Biomédecine. Sciences de la vie. Nervous system -- Degeneration Prion diseases Form Electronic book Author Brown, David R. (David Ronald), 1964- ISBN 9780387239231 0387239235 0387239227 9780387239224 6610234051 9786610234059

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