| Description |
1 online resource (xii, 403 pages) : illustrations |
| Series |
Methods in molecular medicine ; 81 |
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Methods in molecular medicine ; 81.
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| Contents |
Epidemiological investigation of prostate cancer / G.G. Giles -- Human prostate cancer cell lines / P.J. Russell and E.A. Kingsley -- Growth of prostatic epithelial and stromal cells in vitro / D.M. Peehl -- Prostate epithelial stem cell isolation and culture / D.L. Hudson and J.R. Masters -- Generation of immortal human prostate cell lines for the study of prostate cancer / J.S. Rhim -- Spheroids of prostate tumor cell lines / G. Sgouros, W.H. Yang and R. Enmon -- Animal models of prostate cancer / P.J. Russell and D.J. Voeks -- Transgenic mouse models for prostate cancer. Identification of an androgen-dependent promoter and creation and characterization of the long probasin promoter-Large T antigen (LPB-Tag) model / S. Kasper [and others] -- In vivo models of human prostate cancer bone metastasis / J.M. Brown -- Effects of fixation on tissues / E. Mortensen and J.M. Brown -- Background, methods, and protocols for the histopathological diagnosis of prostate carcinoma / W. Delprado -- Realizing the potential of ejaculate/seminal fluid in detecting and predicting natural history / R.A. Gardiner [and others] -- Bisulfite methylation analysis of tumor suppressor genes in prostate cancer from fresh and archival tissue samples / S.J. Clark, D.S. Millar and P. Molloy -- Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to Kallikrein 4 / T.J. Harvey [and others] -- The androgen receptor CAG repeat and prostate cancer risk / P.E. Clark, R.A. Irvine and G.A. Coetzee -- Studies on androgen receptor mutations and amplification in human prostate cancer / Z. Culig [and others] -- Proteomics in the analysis of prostate cancer / S. Naaby-Hansen [and others] -- Application of gene microarrays in the study of prostate cancer / C.C. Nelson [and others] -- Enhancer trap method using a green fluorescent protein reporter plasmid for cloning tissue-specific enhancers active in prostate cells / F. Watt and P. Molloy -- Targeted alpha therapy of prostate cancer / B.J. Allen [and others] -- Phenotypic and functional differences of dendritic cells generated under different in vitro conditions / S.E. McArdle [and others] -- Flavonoid compounds in the prevention and treatment of prostate cancer / G.E. Kelly and A.J. Husband |
| Summary |
With the prostate as the second leading site of cancer among males in Western society, the need to know why certain prostate cancers remain localized while others become aggressive and metastasize has become critical for the care of patients. In Prostate Cancer Methods and Protocols, leading investigators present basic and advanced molecular methods that reveal those markers essential for more accurate diagnoses of specific diseases, and in developing new treatment strategies. The techniques range from in vitro methods to in vivo models of prostate cancer. New methods for the accurate diagnosis of prostate cancer are also offered, including histological assessment, studies of cells in semen, and methylation analysis of the GSTpi, a potential prostate cancer-specific marker. Additional approaches, including proteome and microarray analyses, address such issues as assessing changes in the androgen receptor and studying the enzymes secreted by prostate cancer cells. New strategies for the treatment of refractory disease cover the role of flavonoids, targeted alpha therapy, methods for implementing immune therapy, and prostate-specific gene therapy. Each method is described in step-by-step detail to ensure successful results. Comprehensive and cutting-edge, Prostate Cancer Methods and Protocols provides access to the many powerful tools needed by scientists engaged in prostate cancer research today, as well as up-to-date reviews on several key aspects of the disease |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Prostate -- Cancer -- Molecular diagnosis
|
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Prostatic Neoplasms -- diagnosis
|
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Molecular Diagnostic Techniques
|
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Prostate -- Cancer -- Molecular diagnosis
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Prostaatkanker.
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Wetenschappelijke technieken.
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| Genre/Form |
Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
|
| Author |
Russell, Pamela J. (Pamela Joan)
|
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Jackson, Paul, 1961-
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Kingsley, Elizabeth A. (Elizabeth Anne)
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| ISBN |
0896039781 |
|
9780896039780 |
|
9781592593729 |
|
1592593720 |
|
1280842504 |
|
9781280842504 |
|
9786610842506 |
|
6610842507 |
|
