Title Intrinsically disordered proteins / Vladimir N. Uversky

Published Cham : Springer, 2014

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Description 1 online resource (xv, 61 pages) : illustrations (some color) Series SpringerBriefs in molecular science. Protein folding and structure SpringerBriefs in molecular science. Protein folding and structure, 2191-5407 Contents Introducing the phenomenon of protein intrinsic disorder -- Peculiar amino acid sequences of soluble IDPs -- Natural abundance of IDPs/IDPRs -- Wavy evolution of intrinsic disorder: Reinventing the wheel -- Structural heterogeneity of IDPs: When almost everything is possible -- Typical functions of IDPs and IDPRs -- Binding promiscuity and multitude of the disorder-based binding modes -- IDPs/IDPRs in human diseases -- IDPs as potential drug targets -- Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles Summary In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas Analysis geneeskunde medicine biochemie biochemistry chemie chemistry eiwitten proteins Proteins and Enzymes Eiwitten en enzymen Bibliography Includes bibliographical references Notes Online resource; title from PDF title page (SpringerLink, viewed August 18, 2014) Print version record Subject Proteins -- Structure Proteins -- Conformation. Intrinsically Disordered Proteins Protein Conformation SCIENCE -- Life Sciences -- Biochemistry. Proteins -- Conformation Proteins -- Structure Form Electronic book ISBN 9783319089218 3319089218 331908920X 9783319089201

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