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Title Aggregation of therapeutic proteins / edited by Wei Wang, Christopher J. Roberts
Published Hoboken, N.J. : Wiley, [2010]
Online access available from:
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Description 1 online resource (xxii, 486 pages) : illustrations (some color)
Contents AGGREGATION OF THERAPEUTIC PROTEINS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: Fundamental Structures and Behaviors of Proteins; CHAPTER 2: Protein Aggregation Pathways, Kinetics, and Thermodynamics; CHAPTER 3: Identification and Impact of Aggregation-Prone Regions in Proteins and Therapeutic Monoclonal Antibodies; CHAPTER 4: External Factors Affecting Protein Aggregation; CHAPTER 5: Experimental Detection and Characterization of Protein Aggregates; CHAPTER 6: Approaches to Control Protein Aggregation during Bulk Production
Summary "While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Aggregation of Therapeutic Proteins provides an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. This book also covers an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins. The knowledge in this book will help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area"--Provided by publisher
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Aggregation (Chemistry)
Protein drugs.
Cell Aggregation.
Protein Conformation.
Protein Folding.
Recombinant Proteins -- metabolism.
Recombinant Proteins -- therapeutic use.
Form Electronic book
Author Roberts, Christopher John, 1972-
Wang, Wei, 1957 March 10-
LC no. 2010008428
ISBN 0470769815 (electronic bk.)
0470769823 (electronic bk.)
9780470769812 (electronic bk.)
9780470769829 (electronic bk.)