Title Computational protein-protein interactions / editors, Ruth Nussinov and Gideon Schreiber

Published Boca Raton : CRC Press/Taylor & Francis, 2009

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Description 1 online resource Contents Basic principles of protein-protein interaction / Joel Janin -- Low-resolution recognition factors determine major characteristics of the energy landscape in protein-protein interaction / Ilya A. Vakser -- The molecular architecture of protein-protein binding sites / Eric J. Sundberg -- Mapping protein function by combinatorial mutagenesis / Gabor Pal and Sachdev S. Sidhu -- The association of protein-protein complexes / Gideon Schreiber -- Computational simulations of protein-protein and protein-nucleic acid association / Georgi V. Pachov, Razif R. Gabdoulline, and Rebecca C. Wade -- Computational design of protein-protein interactions / Julia M. Shifman -- Protein-protein docking / Howook Hwang, Brian Pierce, and Zhiping Weng -- Prediction of protein interaction sites / Yanay Ofran -- Predicting molecular interactions in structural proteomics / Irina Kufareva and Ruben Abagyan -- Rearrangements and expansion of the domain content in proteins frequently increase the protein connectivity in the protein-protein interaction network / Inbar Cohen-Gihon, Roded Sharan, and Ruth Nussinov -- Intrinsically disordered proteins and their recognition functions / Vladimir N. Uversky [and others] -- Identification of druggable hot spots on proteins and in protein-protein interfaces / Dmitri Beglov [and others] -- Designing protein-protein interaction inhibitors / Matthieu Montes Summary A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this text incorporates different views of the same biochemical problem from sequence to structure to energetics Bibliography Includes bibliographical references and index Subject Protein-protein interactions -- Computer simulation Protein-protein interactions -- Mathematical models Protein Interaction Mapping Proteins -- physiology Computational Biology -- methods Models, Molecular SCIENCE -- Life Sciences -- Biochemistry. Form Electronic book Author Nussinov, Ruth. Schreiber, Gideon. LC no. 2009012638 ISBN 9781420070071 142007007X

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