The public health impact of the diabetes epidemic -- Risk factors -- Diabetic nephropathy -- Coronary heart disease and diabetes -- Diabetes and cerebrovascular disease -- Erectile dysfunction -- Evidence-based interventions to prevent or retard vascular complications -- Classification and clinical features of neuropathy -- Pathophysiology of diabetic neuropathy -- Epidemiology and natural history of DPN -- Detection/screening/assessment -- Foot ulceration and Charcot arthropathy -- Treatment options -- Management guidelines for diabetic peripheral neuropathy and foot ulceration -- Diabetic retinopathy : epidemiology and risk factors -- Classification and diagnosis of diabetic retinopathy -- Diabetic maculopathy -- Proliferative diabetic retinopathy -- Non-retinal diabetic ocular complications -- Pathophysiology and potential targets for therapeutic intervention -- Protein kinase C -- PKC activation and vascular permeability -- Role of protein kinase C activation in cardiovascular and renal complications of diabetes -- Experimental pharmacology using isoform-selective protein kinase C inhibitors -- Clinical trials with ruboxistaurin
Summary
Diabetes has reached epidemic proportions, and the cardiovascular complications of diabetes are life-threatening and disabling. This book is unique in providing a simple explanation of the biochemical role of PKC in diabetes complications, which allows clinicians to understand why PKC inhibitors (in development) are an exciting prospect for future treatment to slow progression of eye & foot complications. New features of this Second Edition include :.:.; Updated throughout to reflect the impact of recent major clinical trials on current clinical practice.; Includes a major new section on diabe
