| Description |
1 online resource (vii, 256 pages) |
| Series |
Topics in medicinal chemistry, 1862-2461 ; 36 |
|
Topics in medicinal chemistry (Springer (Firm)) ; v. 36. 1862-2461
|
| Contents |
Function, Structure and Topology of Protein Kinases -- Molecular Modeling of Protein Kinases: Current Status and Challenges -- Covalent Kinase Inhibitors: An Overview -- Achieving High Levels of Selectivity for Kinase Inhibitors -- Exploiting Kinase Inhibitors for Cancer Treatment: An Overview of Clinical Results and Outlook -- Case Study on Receptor Tyrosine Kinases EGFR, VEGFR, and PDGFR -- Inhibitors of c-Jun N-Terminal Kinase 3 -- Covalent Janus Kinase 3 Inhibitors |
| Summary |
This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book. Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed April 1, 2021) |
| Subject |
Protein kinases -- Inhibitors.
|
|
Antineoplastic agents.
|
|
Pharmaceutical chemistry.
|
|
Chemistry, Pharmaceutical
|
|
Antineoplastic agents
|
|
Pharmaceutical chemistry
|
|
Protein kinases -- Inhibitors
|
| Form |
Electronic book
|
| Author |
Laufer, Stefan, editor.
|
| ISBN |
9783030681807 |
|
3030681807 |
|
9783030681814 |
|
3030681815 |
|
9783030681821 |
|
3030681823 |
|
