Title Protein-protein interactions / edited by Michael D. Wendt

Published Berlin ; London : Springer, 2012

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Description 1 online resource Series Topics in medicinal chemistry ; 8 Topics in medicinal chemistry ; 8 Contents Protein-Protein Interactions as Drug Targets / Michael D. Wendt -- Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics / Shaomeng Wang, Yujun Zhao, Denzil Bernard, Angelo Aguilar and Sanjeev Kumar -- The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer / Kurt Deshayes, Jeremy Murray and Domagoj Vucic -- Protein-Protein Interaction Targets to Inhibit HIV-1 Infection / John F. Kadow, David R. Langley, Nicholas A. Meanwell, Richard Pracitto and Michael A. Walker, et al. -- Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion: A Focus on Respiratory Syncytial Virus / Nicholas A. Meanwell and David R. Langley -- Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces / Andrew B. Mahon, Stephen E. Miller, Stephen T. Joy and Paramjit S. Arora -- The Discovery of Navitoclax, a Bcl-2 Family Inhibitor / Michael D. Wendt Summary Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang, Yujun Zhao, Denzil Bernard, Angelo Aguilar, Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes, Jeremy Murray, Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow, David R. Langley, Nicholas A. Meanwell, Michael A. Walker, Kap-Sun Yeung, Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell, David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion? a Focus on Respiratory Syncytial Virus Andrew B. Mahon, Stephen E. Miller, Stephen T. Joy, Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor Bibliography ReferencesThe Development of Small-Molecule IAP Antagonists for the Treatment of Cancer; 1 Introduction: Biological Rationale; 1.1 The IAP Family of Anti-Apoptotic Proteins; 1.2 Role of IAP Proteins in Apoptotic Pathways; 1.3 IAP Proteins as E3 Ligases and Mediators of Signaling; 1.4 IAP Proteins in Cancer; 2 Pre-Clinical Studies; 2.1 Peptides Based on SMAC; 2.2 Peptides from Phage Display; 2.3 Peptidomimetics: Pan-Specific Monovalent; 2.4 Peptidomimetics: Pan-Specific Bivalent; 2.5 Mechanism of Action; 2.6 Peptidomimetics: c-IAP-Specific Monovalent; 3 Clinical Programs; 4 Conclusion References Notes Print version record Subject Protein-protein interactions. Drug development. Drugs -- Design. Carrier proteins. Proteins -- metabolism Drug Design Drug Discovery -- methods Carrier Proteins SCIENCE -- Life Sciences -- Biochemistry. Science des matériaux. Chimie. Drugs -- Design Carrier proteins Drug development Protein-protein interactions Form Electronic book Author Wendt, Michael D ISBN 9783642289651 3642289657 3642654584 9783642654589

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