Title Misbehaving proteins : protein (mis)folding, aggregation, and stability / edited by Regina M. Murphy, Amos M. Tsai

Published New York : Springer, ©2006

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Description 1 online resource (viii, 353 pages) : illustrations Contents Protein Folding, Misfolding, Stability, and Aggregation -- Mathematical Models and Computational Methods -- Nonnative Protein Aggregation -- Simulations of Protein Aggregation -- Experimental Methods -- Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry -- Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development -- Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales -- Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation -- X-ray Diffraction for Characterizing Structure in Protein Aggregates -- Glass Dynamics and the Preservation of Proteins -- Fundamental Studies in Model Systems -- Folding and Misfolding as a Function of Polypeptide Chain Elongation -- Determinants of Protein Folding and Aggregation in P22 Tailspike Protein -- Factors Affecting the Fibrillation of?-Synuclein, a Natively Unfolded Protein -- Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation -- Protein Product Development -- Self-Association of Therapeutic Proteins -- Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation Summary Provides a collection of theoretical and experimental studies into protein folding, misfolding, aggregation, and stability. This work illustrates the issues faced during the development of protein products. It contains papers that cover advances in computational efforts to examine protein aggregation Analysis eiwitten proteins engineering biochemie biochemistry biotechnologie biotechnology analytische scheikunde analytical chemistry eiwitexpressieanalyse proteomics Proteins and Enzymes Eiwitten en enzymen Bibliography Includes bibliographical references and index Notes Print version record In Springer e-books Subject Protein folding. Cell aggregation. Protein Folding Cell Aggregation SCIENCE -- Life Sciences -- Biochemistry. Cell aggregation. Protein folding. Biomédecine. Sciences de la vie. Cell aggregation Protein folding Proteine Proteinfaltung Aggregat Chemie Aggregat Form Electronic book Author Murphy, Regina M. Tsai, Amos M. ISBN 9780387360638 0387360638 0387305084 9780387305080 6610724210 9786610724215

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