| Description |
1 online resource (374 pages) |
| Contents |
Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives; Contents; Preface; List of Contributors; Part One: General Information; 1: Half-Life Modulating Strategies -- An Introduction; 1.1 Therapeutic Proteins; 1.2 Renal Clearance and FcRn-Mediated Recycling; 1.3 Strategies to Modulate Plasma Half-Life; 1.3.1 Strategies to Increase the Hydrodynamic Radius; 1.3.2 Strategies Implementing FcRn-Mediated Recycling; 1.4 Half-Life Extension Strategies Applied to a Bispecific Single-Chain Diabody -- A Case Study; 1.5 Conclusion; References |
| Summary |
For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals |
| Notes |
Print version record |
| Subject |
Protein drugs -- Design
|
|
Proteins -- Therapeutic use
|
|
Protein drugs -- Design.
|
|
Proteins -- Therapeutic use.
|
| Form |
Electronic book
|
| ISBN |
9783527644797 |
|
3527644792 |
|
