| Description |
1 online resource (ix, 390 pages) : illustrations (some color) |
| Contents |
X-ray study of protein-protein complexes and analysis of interfaces / Joel Janin -- A structural perspective on protein-protein interactions in macromolecular assemblies / Ranjit P. Bahadur -- Energetics of protein-protein interactions / Ilian Jelesarov -- Kinetics of biomacromolecular complex formation: theory and experiment / Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade -- Evolutionary trace of protein functional determinants / Olivier Lichtarge -- Protein-protein docking / Adrien Saladin and Chantal Prevost -- Data-driven docking: using external information to spark the biomolecular rendez-vous / Adrien S.J. Melquiond and Alexandre M.J.J. Bonvin -- High-resolution protein-protein docking / Nir London and Ora Schueler-Furman -- Scoring and refinement of predicted protein-protein complexes / Martin Zacharias -- Motif-mediated protein interactions and their role in disease / Holger Dinkel and Heinrich Sticht -- Prediction and calculation of protein-protein binding affinities and mutation effects / Sébastien Fiorucci, Serge Antonczak and Jérôme Golebiowski -- Small-molecule inhibitors of protein-protein interactions / Thorsten Berg -- Protein dynamics and drug design: the role of molecular simulations / Giulia Morra, Alessandro Genoni and Giorgio Colombo |
| Summary |
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Protein-protein interactions.
|
|
Carrier proteins.
|
|
Proteins -- Conformation.
|
|
Multiprotein Complexes -- chemistry
|
|
Protein Interaction Mapping
|
|
Carrier Proteins
|
|
Protein Conformation
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Proteins -- Conformation
|
|
Carrier proteins
|
|
Protein-protein interactions
|
| Form |
Electronic book
|
| Author |
Zacharias, Martin
|
| LC no. |
2010484189 |
| ISBN |
9781848163409 |
|
1848163401 |
|
1282759841 |
|
9781282759848 |
|
9786612759840 |
|
6612759844 |
|
