Title Protein kinase C in cancer signaling and therapy / Marcelo G. Kazanietz, editor

Published New York : Springer, ©2010

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Description 1 online resource (xiv, 494 pages) Series Current cancer research Current cancer research. Contents Protein kinase C in cancer signaling and therapy: introduction and historical perspective -- Regulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids -- Phorbol esters and diacylglycerol: the PKC activators -- Diacylglycerol signaling: the C1 domain, generation of DAG and termination of signals -- Regulation of PKC by protein-protein interaction in cancer -- Introduction: PKC isozymes in the control of cell function -- Regulation and function of protein kinase C signaling -- PKC and control of the cell cycle -- PKC and the control of apoptosis -- Atypical PKC's, NF-kB and inflammation -- Introduction: PKC and cancer -- Protein kinase C, p53, and DNA damage -- PKCs as mediators of the hedgehog and Wnt signaling pathways -- PKC-PKD interplay in cancer -- Transgenic mouse models to investigate functional specificity of protein kinase C isoforms in the development of squamous cell carcinoma, a nonmelanoma human skin cancer -- PKC isozymes and skin cancer -- PKC and breast cancer -- PKC and prostate cancer -- Protein kinase C and lung cancer -- Introduction [PKC isozymes as targets for cancer therapy] -- PKC and resistance to chemotherapeutic agents -- PKCd as a target for chemotherapeutic drugs -- Atypical PKCs as targets for cancer therapy Summary The Protein Kinase C (PKC) serine-threonine kinases represent one & tile first families of signaling molecules implicated in carcinogenesis. Originally identified as the intracellular targets for the phorbol esters, natural products with tumor promoting activity, PKC isozymes rare known to mediate the actions of growth factors and hormones, and have been widely implicated in the control of cell proliferation, survival, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, expression of PKC isozymes is altered in various types of cancers and correlates in many cases with the progression of the disease. Over-expression off KC isozymes in mouse models can lead to the development of cancer. PKCs also mediate the action of chemotherapeutic drugs or in some cases they are involved in the resistance to chemotherapeutic agents. More importantly, small molecule PKC inhibitors have been developed with significant anti-cancer activity. The relevance of fitC isozymes in cancer signaling is therefore remarkable Protein Kinase C in Cancer Signaling and Therapy is composed of twenty-three chapters written by leading experts in the field. The book is divided into four sections: Regulation of PKC isozyme function: from genes to biochemistry, PKC isozymes in the control of cell function, PKC isozymes in cancer, and PKC isozymes as targets for cancer therapy. Each section of Protein Kinase C in Cancer Signaling and Therapy begins with an introduction by an established professional in the field of PKC, followed by chapters that elucidate the importance of PKC in current cancer research. --Book Jacket Analysis neoplasms farmacologie pharmacology toxicologie toxicology biomedische wetenschappen biomedicine Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Print version record In Springer eBooks Subject Cancer -- Treatment. Protein kinase C. Toxicology. Neoplasms -- drug therapy Protein Kinase C -- therapeutic use Intercellular Signaling Peptides and Proteins Protein Kinase C Toxicology toxicology. SCIENCE -- Life Sciences -- Biochemistry. Protein kinase C. Neoplasms -- drug therapy. Protein Kinase C -- therapeutic use. Intercellular Signaling Peptides and Proteins. Cancer -- Treatment. Médecine. Cancer -- Treatment Protein kinase C Form Electronic book Author Kazanietz, Marcelo G., 1962- LC no. 2010929851 ISBN 9781607615439 1607615436 9781607615422 1607615428

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