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E-book

Title Sparking signals : kinases as molecular signatransducers and pharmacological drug targets in inflammation / G. Baier [and others]
Published Berlin ; New York : Springer, 2008

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Description 1 online resource (xiv, 185 pages) : illustrations
Series Ernst Schering Foundation symposium proceedings, 0947-6075 ; 2007/3
Ernst Schering Foundation symposium proceedings ; 2007/3. 0947-6075
Contents Proteomics-Based Strategies in Kinase Drug Discovery -- PKC Isotype Functions in T Lymphocytes -- Migration, Cell-Cell Interaction and Adhesion in the Immune System -- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts -- Fragment-Based Drug Discovery Using Rational Design -- Systems Biology of T Cell Activation -- Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice -- Sensing, Presenting, and Regulating PAMPS -- The Role of Diacylglycerol Kinases in T Cell Anergy
Summary "Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups."--Jacket
Analysis Sparking signals
Molecular signatransducers
Pharmacological drug targets
Inflammation
Bibliography Includes bibliographical references
Notes Print version record
In Springer eBooks
Subject Pharmacokinetics -- Congresses
Protein kinases -- Congresses
Drug targeting -- Congresses
Cellular signal transduction -- Congresses
Anti-inflammatory agents -- Pharmacokinetics -- Congresses
Toxicology.
Biochemistry.
Inflammation -- drug therapy
Anti-Inflammatory Agents -- therapeutic use
Protein Kinase Inhibitors -- therapeutic use
Protein Kinases -- drug effects
Toxicology
Biochemistry
toxicology.
biochemistry.
MEDICAL -- Pharmacology.
Anti-Inflammatory Agents -- therapeutic use.
Protein Kinase Inhibitors -- therapeutic use.
Protein Kinases -- drug effects.
Pharmacokinetics.
Protein kinases.
Drug targeting.
Cellular signal transduction.
Anti-Inflammatory Agents -- pharmacokinetics.
Medicine.
Inflammation -- drug therapy.
Biomédecine.
Sciences de la vie.
Cellular signal transduction
Drug targeting
Pharmacokinetics
Protein kinases
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Baier, G. (Gottfried)
Ernst Schering Research Foundation.
LC no. 2007943076
ISBN 9783540735014
3540735011
9783540735007
3540735003
128124158X
9781281241580