| Description |
1 online resource (viii, 415 pages) : illustrations (chiefly color) |
| Series |
Advances in experimental medicine and biology, 2214-8019 ; volume 1275 |
|
Advances in experimental medicine and biology ; v. 1275. 0065-2598
|
| Contents |
Protein kinase-mediated decision between the life and death -- Aging and protein kinases -- The connection between cell fate and telomere -- Dark-side of exosomes -- Signal transduction in immune cells and protein kinases -- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity -- Combined toxicity of metal nanoparticles: comparison of individual and mixture particles effect -- Protein kinases signaling in pancreatic beta-cells death and type diabetes -- Bile acid toxicity and protein kinases -- N-Methyl-D-aspartate receptor signaling-protein kinases crosstalk in cerebral ischemia -- Alzheimer's disease and protein kinases -- Bacterial protein kinases -- Indoleamine 2,3-dioxygenase activity-induced acceleration of tumor growth, and protein kinases-related novel therapeutics regimens -- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy -- Protein kinases in hematological disorders -- Metabolic stress and immunity: nutrient-sensing kinases and tryptophan metabolism |
| Summary |
"Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on "Protein Kinases" related pathways that threaten human health and life"--Publisher's description |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from resource home page (EBSCOhost, viewed February 17, 2021) |
| Subject |
Protein kinases.
|
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Proteomics.
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Phosphorylation.
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Cellular signal transduction.
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Protein Kinases -- genetics
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Phosphorylation
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Proteins -- metabolism
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Proteomics
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Signal Transduction
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Protein Kinases
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Phosphorylation
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Cellular signal transduction
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Protein kinases
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Proteomics
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| Form |
Electronic book
|
| Author |
Engin, Ayse Basak, editor
|
|
Engin, Atilla, editor
|
| ISBN |
9783030498443 |
|
3030498441 |
|
9783030498450 |
|
303049845X |
|
9783030498467 |
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3030498468 |
|
