Kinases and cancer -- Protein kinase structure, function, and regulation -- Receptor tyrosine kinases -- Nonreceptor tyrosine kinases -- Intracellular signal transduction cascades -- Cell cycle control -- Structural biochemistry of kinase inhibitors -- Tyrosine kinase inhibitors -- Angiokinase inhibitors -- Intracellular signaling kinase inhibitors -- Current challenges and future directions
Summary
An expert guide to targeting protein kinases in cancer therapy. Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharma-ceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapydefines the structural features of protein kinases and examines their cellular func-tions. Combining kinase biology with
