Amyloid precursor protein sorting and processing : transmitters, hormones, and protein phosphorylation mechanisms / Sam Gandy [and others] -- Intramembrane proteolysis by gamma-secretase and signal peptide peptidases / Regina Fluhrer and Christian Haass -- Axonal transport and neurodegenerative disease / Erika L.F. Holzbaur -- Simple cellular solutions to complex problems / Susan Lindquist and Karen L. Allendoerfer -- Tau and intracellular transport in neurons / E.-M. Mandelkow [and others] -- Signaling between synapse and nucleus during synaptic plasticity / Kwok-On Lai, Dan Wang, and Kelsey C. Martin -- Axonal transport of neurotrophic signals : an Achilles' heel for neurodegeneration? / Ahmad Salehi [and others] -- Membrane trafficking and targeting in Alzheimer's disease / Lawrence Rajendran and Kai Simons -- Huntington's disease : function and dysfunction of huntingtin in axonal transport / Frédéric Saudou and Sandrine Humbert -- The role of retromer in neurodegenerative disease / Claire F. Skinner and Matthew N.J. Seaman -- Regulation of endocytic trafficking of receptors and transporters by ubiquitination : possible role in neurodegenerative disease / Alexander Sorkin -- The sortilin-related receptor SORL1 is functionally and genetically associated with Alzheimer's disease / Ekaterina Rogaeva [and others] -- Regulation of transport and processing of amyloid precursor protein by the sorting receptor SORLA / Thomas E. Willnow, Michael Rohe, and Vanessa Schmidt
Summary
Explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them
