Title Jak-Stat signaling : from basics to disease / Thomas Decker, Mathias Müller, editors

Published Vienna ; New York : Springer, ©2012

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Description 1 online resource : illustrations Contents The Continuing Fascination with Jaks and Stats: An Introduction / Thomas Decker and Mathias Müller -- Regulation of JAKs: Insights Gleaned from the Functional Protein Domains / Claude Haan, Daniela Ungureanu, Tuija Pekkala, Olli Silvennoinen and Serge Haan -- Nuclear Functions of the Janus Kinases / Mark A. Dawson and Andrew J. Bannister -- Self-association of STAT Proteins from Monomers to Paracrystals / Mathias Droescher and Uwe Vinkemeier -- How Stats Interact with the Molecular Machinery of Transcriptional Activation / Amanda M. Jamieson, Matthias Farlik and Thomas Decker -- Nongenomic Functions of STAT3 / Daniel J. Gough, Pravin Sehgal and David E. Levy -- Evolution of Jak and Stat Proteins / Claus Vogl, Priyank Shukla and Ingo Ebersberger -- JAK/STAT and Chromatin Regulation in Drosophila / Kriti Gaur and Willis X. Li -- JAK/STAT Signaling and Invertebrate Immune Responses / Feng Zhou and Hervé Agaisse -- Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development / Harini Nivarthi, Katrin Friedbichler and Richard Moriggl -- Regulation of Dendritic Cell Development by STATs / Haiyan S. Li and Stephanie S. Watowich STAT Transcription Factors: Controlling All Aspects of NK Cell Biology / Eva Maria Putz, Eva Zebedin and Veronika Sexl -- Function of JAKs and STATs in Lymphocytes: Bench to Bedside / Alejandro Villarino, Xiang-Ping Yang, Kiyoshi Hirahara, Yuka Kanno and John J. O' Shea, et al. -- The Role of Janus Kinases in Hematopoietic Malignancies / Damla Olcaydu and Robert Kralovics -- Activation of Janus Kinases During Tumorigenesis / Jeffrey W. Schmidt and Kay-Uwe Wagner -- STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer / Paulina Rampetsreiter and Robert Eferl -- Universal and Specific Functions of STAT3 in Solid Tumours / Lidia Avalle, Gabriella Regis and Valeria Poli -- Impact of STAT5 on Normal Tissue Development and Cancer / Maria M. Caffarel and Christine J. Watson -- Crosstalk with the Jak-STAT Pathway in Inflammation / Lionel B. Ivashkiv -- Activation and Inhibition of JAK-STAT Signal Transduction by RNA Viruses / Curt M. Horvath -- Multifaceted Antiviral Actions of Interferon-stimulated Gene Products / Birgit Strobl, Nicole R. Leitner and Mathias Müller -- Interferon Regulation of the Innate Response to Bacteria / Ali Abdul-Sater and Christian Schindler Summary JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues Analysis Life sciences Oncology Medical genetics Immunology Hematology Cytology Stem cells Cell Biology Cancer Research Gene Function Bibliography Includes bibliographical references and index Notes English Subject Cellular signal transduction. Molecular biology. Cytokines. Life sciences. Transcription factors. Protein-tyrosine kinase. Cell receptors. Proteins. Protein kinases. Physical sciences. Carrier proteins. Membrane proteins. Phosphotransferases. Transferases. Enzymes. Physiology. Cell physiology. Biological Science Disciplines Transcription Factors Receptors, Immunologic Protein-Tyrosine Kinases Receptors, Cell Surface Proteins Protein Kinases Chemical Phenomena Natural Science Disciplines Carrier Proteins Amino Acids, Peptides, and Proteins Phosphotransferases (Alcohol Group Acceptor) Disciplines and Occupations Phenomena and Processes Peptides Membrane Proteins Chemicals and Drugs Phosphotransferases Transferases Enzymes Enzymes and Coenzymes STAT Transcription Factors Physiology Receptors, Cytokine Signal Transduction Janus Kinases Cell Physiological Phenomena Biochemical Phenomena Intracellular Signaling Peptides and Proteins Adaptor Proteins, Signal Transducing Molecular Biology Cytokines molecular biology. biological sciences. protein. physical sciences. enzyme. physiology. SCIENCE -- Life Sciences -- Anatomy & Physiology. Transferases Transcription factors Proteins Protein-tyrosine kinase Protein kinases Physiology Physical sciences Phosphotransferases Membrane proteins Life sciences Enzymes Cell receptors Cell physiology Carrier proteins Cellular signal transduction Cytokines Molecular biology Form Electronic book Author Decker, Thomas Müller, Mathias, 1960- ISBN 9783709108918 3709108918 9783709108901 370910890X 3709117526 9783709117521

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