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Title Protein tyrosine kinases : from inhibitors to useful drugs / edited by Doriano Fabbro and Frank McCormick
Published Totowa, N.J. : Humana Press, ©2006

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Description 1 online resource (xiii, 290 pages) : illustrations (some color)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Protein tyrosine kinases as targets for cancer and other indications / Mark Pearson, Carlos Garcia-Echeverria, Doriano Fabbro -- Inhibitors of signaling interfaces : targeting Src homology 2 domains in drug discovery / Carlos Garcia-Echeverria -- PI 3-kinase inhibition : a target for therapeutic intervention / Peter M. Finan, Stephen G. Ward -- Src as a target for pharmaceutical intervention : potential and limitations / Mira Susa [and others] -- Activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia / Blanca Scheijen, James D. Griffin
JAK kinases in leukemias/lymphomas and multiple myeloma / Renate Burger, Martin Gramatzki -- Glivec (Gleevec, Imatinib, STI571) : a targeted therapy for CML / Elisabeth Buchdunger, Renaud Capedeville -- Platelet-derived growth factor : normal function, role in disease, and applications of PDGF antagonists / Tobias Sjoblom [and others] -- Structural biology of protein tyrosine kinases / Sandra W. Cowan-Jacob [and others] -- Testing of signal transduction inhibitors in animal models of cancer / Terence O'Reilly, Robert Cozens -- Phosphoproteomics in drug discovery and development / Michel F. Moran
Summary In this title, leading researchers, from the Novartis group that pioneered Gleevec/Gliveca and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating 'selective' low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-deriv
Analysis biochemie
biochemistry
levenswetenschappen
life sciences
Biology (General)
Biologie (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Protein-tyrosine kinase -- Inhibitors -- Therapeutic use
Cancer -- Chemotherapy.
Drugs -- Design.
Protein-Tyrosine Kinases -- pharmacology
Protein-Tyrosine Kinases -- therapeutic use
Antineoplastic Agents -- pharmacology
Drug Design
Neoplasms -- drug therapy
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Cancer -- Chemotherapy.
Protein-Tyrosine Kinase -- physiology.
Lymphocyte Specific Protein Tyrosine Kinase p56 (lck) -- physiology.
Neoplasms -- drug therapy.
src-Family Kinases -- physiology.
Protein-tyrosine kinase -- Inhibitors -- Therapeutic use.
Biomédecine.
Sciences de la vie.
Drugs -- Design
Cancer -- Chemotherapy
Form Electronic book
Author Fabbro, D
McCormick, Frank, 1950-
LC no. 2005006248
ISBN 9781592599622
1592599621
9781588293848
158829384X