| Description |
1 online resource (xiii, 290 pages) : illustrations (some color) |
| Series |
Cancer drug discovery and development |
|
Cancer drug discovery and development.
|
| Contents |
Protein tyrosine kinases as targets for cancer and other indications / Mark Pearson, Carlos Garcia-Echeverria, Doriano Fabbro -- Inhibitors of signaling interfaces : targeting Src homology 2 domains in drug discovery / Carlos Garcia-Echeverria -- PI 3-kinase inhibition : a target for therapeutic intervention / Peter M. Finan, Stephen G. Ward -- Src as a target for pharmaceutical intervention : potential and limitations / Mira Susa [and others] -- Activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia / Blanca Scheijen, James D. Griffin |
|
JAK kinases in leukemias/lymphomas and multiple myeloma / Renate Burger, Martin Gramatzki -- Glivec (Gleevec, Imatinib, STI571) : a targeted therapy for CML / Elisabeth Buchdunger, Renaud Capedeville -- Platelet-derived growth factor : normal function, role in disease, and applications of PDGF antagonists / Tobias Sjoblom [and others] -- Structural biology of protein tyrosine kinases / Sandra W. Cowan-Jacob [and others] -- Testing of signal transduction inhibitors in animal models of cancer / Terence O'Reilly, Robert Cozens -- Phosphoproteomics in drug discovery and development / Michel F. Moran |
| Summary |
In this title, leading researchers, from the Novartis group that pioneered Gleevec/Gliveca and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating 'selective' low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-deriv |
| Analysis |
biochemie |
|
biochemistry |
|
levenswetenschappen |
|
life sciences |
|
Biology (General) |
|
Biologie (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Protein-tyrosine kinase -- Inhibitors -- Therapeutic use
|
|
Cancer -- Chemotherapy.
|
|
Drugs -- Design.
|
|
Protein-Tyrosine Kinases -- pharmacology
|
|
Protein-Tyrosine Kinases -- therapeutic use
|
|
Antineoplastic Agents -- pharmacology
|
|
Drug Design
|
|
Neoplasms -- drug therapy
|
|
MEDICAL -- Oncology.
|
|
HEALTH & FITNESS -- Diseases -- Cancer.
|
|
Cancer -- Chemotherapy.
|
|
Protein-Tyrosine Kinase -- physiology.
|
|
Lymphocyte Specific Protein Tyrosine Kinase p56 (lck) -- physiology.
|
|
Neoplasms -- drug therapy.
|
|
src-Family Kinases -- physiology.
|
|
Protein-tyrosine kinase -- Inhibitors -- Therapeutic use.
|
|
Biomédecine.
|
|
Sciences de la vie.
|
|
Drugs -- Design
|
|
Cancer -- Chemotherapy
|
| Form |
Electronic book
|
| Author |
Fabbro, D
|
|
McCormick, Frank, 1950-
|
| LC no. |
2005006248 |
| ISBN |
9781592599622 |
|
1592599621 |
|
9781588293848 |
|
158829384X |
|
