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Proto-Indo-European language -- Grammar, Comparative -- Greek   2
Proto-Indo-European language Greek language Grammar, Comparative   2
Proto-Indo-European language -- History : The precursors of Proto-Indo-European : the Indo-Anatolian and Indo-Uralic hypotheses / edited by Alwin Kloekhorst, Tijmen Pronk  2019 1
Proto-Indo-European language -- Noun : S-Stem Nouns and Adjectives in Greek and Proto-Indo-European : a Diachronic Study in Word Formation  2006 1
Proto-Indo-European language -- Phonology   2
Proto-Indo-European language -- Roots : Greek and Indo-European etymology in action : proto-Indo-European *aǵ- / Raimo Anttila  2000 1
Proto-Indo-European language -- Spain -- History : Advances in Proto-Basque reconstruction with evidence for the Proto-Indo-European-Euskarian hypothesis / by Juliette Blevins  2018 1
Proto-Indo-European language -- Syntax : Proto-Indo-European syntax and its development / edited by Leonid Kulikov, Ghent University ; Nikolaos Lavidas, Aristotle University of Thessaloniki  2015 1
Proto-Indo-European language -- Vowels : The study of Indo-European vocalism in the 19th century : from the beginnings to Whitney and Scherer : a critical-historical account / Wilbur A. Benware  1974 1
Proto-Indo-European language -- Word formation : S-Stem Nouns and Adjectives in Greek and Proto-Indo-European : a Diachronic Study in Word Formation  2006 1
Proto-indo-europees.   2
Proto-industrialisatie. : State corporatism and proto-industry : the Württemberg Black Forest, 1580-1797 / Sheilagh Ogilvie  1997 1
Proto-Li language -- Phonology : A phonological reconstruction of Proto-Hlai / by Peter K. Norquest  2016 1
Proto-Malayan language -- Phonology : The reconstruction of Proto-Malayo-Javanic / Bernd Nothofer  1975 1
  Proto-Oceanic language -- 4 Related Subjects   4
Proto-Oceanic language.   2
 

Proto-oncogene c-ErbB-1 Protein -- See ErbB Receptors


A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS
  1
 

Proto-oncogene c-ErbB-2 -- See Receptor, ErbB-2


A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member
  1
 

Proto-Oncogene, c-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
  1
 

Proto-Oncogene, c-src -- See Genes, src


Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20
  1
 

Proto-Oncogene, L-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
  1
 

Proto-Oncogene, N-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
  1
 

Proto-Oncogene Products c-myc -- See Proto-Oncogene Proteins c-myc


Basic helix-loop-helix transcription factors encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis
  1
 

Proto-Oncogene Protein Akt -- See Proto-Oncogene Proteins c-akt


Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells
  1
 

Proto-Oncogene Protein B-raf -- See Proto-Oncogene Proteins B-raf


A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2
  1
 

Proto-Oncogene Protein, c-akt -- See Proto-Oncogene Proteins c-akt


Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells
  1
 

Proto-Oncogene Protein, erbB-1 -- See ErbB Receptors


A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS
  1
 

Proto-Oncogene Protein, erbB-2 -- See Receptor, ErbB-2


A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member
  1
 

Proto-Oncogene Protein HER-2 -- See Receptor, ErbB-2


A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member
  1
 

Proto-Oncogene Protein, MLL -- See Myeloid-Lymphoid Leukemia Protein


Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS
  1
 

Proto-oncogene Protein Neu -- See Receptor, ErbB-2


A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member
  1
 

Proto-Oncogene Protein p185(neu) -- See Receptor, ErbB-2


A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member
  1
 

Proto-Oncogene Protein RAC -- See Proto-Oncogene Proteins c-akt


Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells
  1
 

Proto-Oncogene Proteins c-akt1 -- See Proto-Oncogene Proteins c-akt


Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells
  1
 

Proto-Oncogene Proteins c-akt2 -- See Proto-Oncogene Proteins c-akt


Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells
  1
 

Proto-Oncogene Proteins c-akt3 -- See Proto-Oncogene Proteins c-akt


Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells
  1
Proto-Oncogene Proteins c-bcl-2 : BCL-2 family proteins : methods and protocols / edited by Evripidis Gavathiotis  2018 1
Proto-Oncogene Proteins c-bcl-2 -- metabolism : BCL-2 protein family : essential regulators of cell death / edited by Claudio Hetz  2010 1
Proto-Oncogene Proteins c-bcl-2 -- physiology : BCL-2 protein family : essential regulators of cell death / edited by Claudio Hetz  2010 1
 

Proto-Oncogene Proteins c-erbB-2 -- See Receptor, ErbB-2


A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member
  1
Proto-Oncogene Proteins c-myc : The Myc/Max/Mad transcription factor network / R.N. Eisenmann (ed.)  2006 1
 

Proto-Oncogene Proteins c-rel -- See Also I-kappa B Proteins


A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus
  1
 

Proto-Oncogene Proteins, met -- See Proto-Oncogene Proteins c-met


Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia
  1
 

Proto-Oncogene Proteins MLL -- See Myeloid-Lymphoid Leukemia Protein


Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS
  1
  Proto-oncogene proteins, Myc -- 2 Related Subjects   2
 

Proto-Oncogene Proteins p21(ras) -- See Also Costello Syndrome


Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome)
  1
  Proto-oncogenes -- 3 Related Subjects   3
Proto-oncogenes   2
 

Proto-Oncogenes, c-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
  1
 

Proto-Oncogenes, c-src -- See Genes, src


Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20
  1
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