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Title The chemical biology of long noncoding RNAs / Stefan Jurga, Jan Barciszewski, editors
Published Cham, Switzerland : Springer, [2020]

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Description 1 online resource (x, 544 pages) : illustrations (some color)
Series RNA technologies, 2197-9731 ; volume 11
RNA technologies, 2197-9731
Contents Intro -- Preface -- Introduction -- Long Non-protein Coding RNAs -- Contents -- Long Non-coding RNAs Diversity in Form and Function: From Microbes to Humans -- 1 Introduction: Identification, Classification, and Properties of LncRNAs -- 2 Discovery of LncRNAs -- 2.1 Tiling Arrays -- 2.2 High-Throughput Sequencing Serial Analysis of Gene Expression (SAGE) -- 2.3 Histone Modification Signatures -- 2.4 Cap Analysis of Gene Expression (CAGE) -- 2.5 RNA Sequencing (RNA-Seq) -- 2.6 Direct RNA Sequencing (Oxford Nanopore) -- 3 Biogenesis of LncRNAs -- 3.1 Processing of LncRNAs
3.2 Regulation of LncRNA Transcription -- 3.3 Degradation of LncRNAs -- 3.4 LncRNA Subcellular Localization -- 3.5 LncRNA Structure and Structure-Mediated Interactions -- 4 Human LncRNAs -- 4.1 X-inactive Specific Transcript (XIST) -- 4.2 MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) -- 4.3 HOX Transcript Antisense RNA (HOTAIR) -- 4.4 Steroid Receptor RNA Activator (SRA) -- 4.5 Maternally Expressed 3 (MEG3) -- 5 Plant LncRNAs -- 5.1 Cold of Winter-Induced Non-coding RNA (COLDAIR) -- 5.2 Cold-Induced Long Antisense Intragenic RNA (COOLAIR)
5.3 Cold of Winter-Induced Non-coding RNA from the Promoter (COLDWRAP) -- 5.4 Auxin-Regulated Promoter Loop RNA (APOLO) -- 6 Bacterial LncRNAs -- 6.1 Ornate, Large, Extremophilic RNAs (OLE) -- 6.2 Giant, Ornate, Lake- and Lactobacillales-Derived (GOLLD) -- 6.3 HNH Endonuclease-Associated RNA and ORF (HEARO RNA) -- 7 Viral LncRNAs -- 7.1 Adenovirus Virus-Associated RNAs (VA RNAs) -- 7.2 Kaposiś Sarcoma-Associated Herpesvirus (KSHV) Polyadenylated Nuclear RNA (PAN) -- 7.3 Human Cytomegalovirus LncRNAs -- 7.4 Human Immunodeficiency Virus-1 Antisense RNA (ASP)
7.5 Subgenomic Flaviviral RNAs (sfRNAs) -- 8 LncRNA and Therapy -- 9 Conclusions -- References -- Evolving Roles of Long Noncoding RNAs -- 1 Introduction -- 2 The Classification, Localization, and Structures of lncRNAs -- 2.1 Definition and Classification of lncRNAs -- 2.1.1 lncRNAs -- 2.1.2 lncRNAs Classification -- 2.2 Subcellular Localization -- 2.3 Structural Studies -- 2.3.1 Structural Determination of lncRNAs and Potential Structural Analysis Techniques -- 2.3.2 lncRNA Secondary Structure Predication -- 2.3.3 Predict lncRNA Tertiary Structure -- 2.3.4 Structure-Function Relationships
3 Mechanisms of Action and Physiological Functions -- 3.1 lncRNA Interaction with Proteins -- 3.2 lncRNA Interaction with DNA -- 3.3 lncRNA Interaction with RNAs -- 4 lncRNAs as Potential Biomarkers and Therapeutic Targets in Neurological Disorders -- 4.1 Alzheimerś Disease (AD) -- 4.2 Spinal Muscular Atrophy (SMA) -- 4.3 Spinal Cord Injury (SCI) -- 4.4 Huntingtonś Disease (HD) -- 4.5 Angelman Syndrome (AS) -- 4.6 Schizophrenia (SZ) -- 4.7 Dravet Syndrome (DS) -- 4.8 Parkinsonś Disease (PD) -- 5 Advances in Antisense Oligonucleotide (ASO) Chemistry for Targeted Delivery
Summary This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed December 3, 2020)
Subject Non-coding RNA.
Nucleic acids.
Biomedical engineering.
RNA, Long Noncoding -- chemistry
RNA, Untranslated
biomedical engineering.
Biochemistry.
Biomedical engineering.
Medical genetics.
Science -- Life Sciences -- Biochemistry.
Medical -- Allied Health Services -- Medical Technology.
Medical -- Genetics.
Biomedical engineering
Human genetics
Nucleic acids
Genre/Form Electronic books
Form Electronic book
Author Jurga, Stefan, editor.
Barciszewski, Jan, editor.
ISBN 303044743X
9783030447434