| Description |
1 online resource (1 volume) |
| Series |
Molecular biology intelligence unit |
|
Molecular biology intelligence unit (Unnumbered)
|
| Contents |
Features of nonsense-mediated mRNA decay in Saccharomyces cerevisiae / Kristian E. Baker and Roy Parker -- All termination events are not equal : premature termination in yeast is aberrant and triggers NMD / Nadia Amrani and Allan Jacobson -- Endogenous substrates of the yeast NMD pathway / Feng He and Allan Jacobson -- NMD in mammalian cells : a history / Lynne E. Maquat -- Human Upf proteins in NMD / Guramrit Singh and Jens Lykke-Andersen -- NMD and the immune system / Jayanthi P. Gudikote and Miles F. Wilkinson -- Role of SMG-1-mediated phosphorylation of Upf1 in NMD / Akio Yamashita, Isao Kashima, and Shigeo Ohno -- Physiologic substrates and functions for mammalian NMD / Neda A. Sharifi and Harry C. Dietz -- NMD and human disease / Jill A. Holbrook [and others] -- Therapies of nonsense-associated diseases / Kim M. Keeling, Ming Du, and David M. Bedwell -- NMD in Caenorhabditis elegans / Philip Anderson |
|
NMD in Drosophila : a snapshot into the evolution of a conserved mRNA surveillance pathway / Isabelle Behm-Ansmant and Elisa Izaurralde -- NMD in plants / Ambro van Hoof and Pamela J. Green -- Regulation of gene expression by coupling of alternative splicing and NMD / David A.W. Soergel, Liana F. Lareau, and Steven E. Brenner -- NMD and the evolution of eukaryotic gene structure / Michael Lynch, Xin Hong, and Douglas G. Scofield -- The SMG-1 kinase : at the crossroads of mRNA surveillance and stress response pathways / Robert T. Abraham and Vasco Oliveira -- Staufen1-mediated mRNA decay : a Upf1-dependent pathway / Yoon Ki Kim and Lynne E. Maquat -- Upf1 regulates mammalian histone mRNA decay / Handan Kaygun and William F. Marzluff -- S. cerevisiae Est1/H. sapiens SMG6 protein family members function in telomere metabolism / Claus M. Azzalin, Sophie Redon, and Joachim Lingner -- Nonsense-associated altered splicing / Zuo Zhang and Adrian R. Krainer |
| Summary |
This is the first book devoted to NMD. The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of posttrancriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cerevisiae and mammals, from which most NMD data derive. Chapters within these sections discuss the two basic ways cells differentiate between a termination codon that elicits NMD and one that does not. NMD in S. cerevisiae, D. melanogaster and, probably, C. elegans and plants appears to be triggered by an abn |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Messenger RNA -- Stability
|
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RNA -- Stability
|
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Saccharomyces cerevisiae.
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Genetic regulation.
|
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Mammals.
|
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RNA Stability -- physiology
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RNA, Messenger -- genetics
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Mammals
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Protein Biosynthesis
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RNA Stability -- genetics
|
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Saccharomyces cerevisiae
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Gene Expression Regulation
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Mammalia (class)
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SCIENCE -- Life Sciences -- Biochemistry.
|
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Mammals
|
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Genetic regulation
|
|
Messenger RNA -- Stability
|
|
RNA -- Stability
|
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Saccharomyces cerevisiae
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Stabilité de l'ARN -- physiologie.
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ARN messager -- génétique.
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Stabilité de l'ARN -- génétique.
|
|
ARN -- Stabilité.
|
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Saccharomyces cerevisiae.
|
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Régulation génétique.
|
| Form |
Electronic book
|
| Author |
Maquat, Lynne
|
| ISBN |
142376658X |
|
9781423766582 |
|
1598759515 |
|
9781598759518 |
|
9781587064012 |
|
1587064014 |
|
