Title Cancer and noncoding RNAs. Volume 1 / edited by Dr. Jayprokas Chakrabarti, M. Sc., Ph. D., Principal Investigator/Senior Professor, Indian Association for the Cultivation of Sciences (IACS), Kolkata, India, Dr. Sanga Mitra, Visiting Fellow, NIDDK, NIH, Bethesda, MD

Published London : Academic Press, an imprint of Elsevier, [2017] ©2018

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Description 1 online resource Series Translational epigenetics series Translational epigenetics series. Contents Front Cover -- Cancer and Noncoding RNAs -- Series Page -- Cancer and Noncoding RNAs -- Copyright -- Contents -- List of Contributors -- 1 -- INTRODUCTION -- CANCER: THE CRAB -- TYPES OF CANCER -- TUMOR, NODE, METASTASIS STAGING OF CANCER -- PRIMARY TUMOR (T) -- REGIONAL LYMPH NODES (N) -- DISTANT METASTASIS (M) -- MOLECULAR DELINEATION OF CANCER -- GENETIC ALTERATION SIGNATURES IN CANCER -- COMPETING ENDOGENOUS RNAS HYPOTHESIS -- EPIGENETIC ALTERATION SIGNATURES IN CANCER -- THERAPEUTIC POTENTIAL OF NONCODING RNA IN CANCER -- REFERENCES 1 -- NON-CODING RNAs: FINE-TUNING CANCER2 -- MIRNA AND CANCER: A DEADLY LIAISON? -- INTRODUCTION -- CELL CYCLE, PROLIFERATION, AND SURVIVAL -- ANGIOGENESIS AND METASTASIS -- TUMOR MICROENVIRONMENT -- CANCER STEM CELLS AND CHEMORESISTANCE -- PERSPECTIVE -- ACKNOWLEDGMENTS -- REFERENCES -- 3 -- ALTERATION OF MICRORNA BIOGENESIS PATHWAYS IN CANCERS -- INTRODUCTION -- MICRORNA BIOGENESIS PATHWAY IN ANIMALS -- ALTERATION IN MICRORNA TRANSCRIPTION -- ALTERATION IN PRIMARY MICRORNA PROCESSING IN NUCLEUS -- ALTERATION IN PRE-MICRORNA EXPORT INTO CYTOPLASM ALTERATION IN CYTOPLASMIC PRE-MICRORNA PROCESSINGALTERATION IN RNA-INDUCED SILENCING COMPLEX -- CONCLUSION -- REFERENCES -- 4 -- MICRORNAS IN EXOSOMES IN CANCER -- CHAPTER OVERVIEW -- INTRODUCTION TO MICRORNAS -- BRIEF DESCRIPTION OF CANONICAL MICRORNA BIOGENESIS -- BRIEF DESCRIPTION OF MICRORNA FUNCTION -- BRIEF DESCRIPTION OF EXOSOMES -- BRIEF DESCRIPTION OF EXOSOMAL SORTING OF MICRORNAS -- EXOSOMAL MICRORNA IN CANCERâ#x80;#x94;INVASION AND METASTASIS -- EXOSOMAL MICRORNA IN CANCERâ#x80;#x94;ANGIOGENESIS -- EXOSOMAL MICRORNAS IN CANCERâ#x80;#x94;REGULATING METABOLISM EXOSOMAL MICRORNA IN CANCERâ#x80;#x94;CROSS TALK WITH THE IMMUNE SYSTEMEXOSOMAL MICRORNA IN CANCERâ#x80;#x94;CHEMORESISTANCE AND CHEMOSENSITIVITY -- EXOSOMAL MICRORNA IN CANCERâ#x80;#x94;POTENTIAL BIOMARKERS AND LIQUID BIOPSY -- EXOSOMAL MICRORNA IN CANCERâ#x80;#x94;CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- GLOSSARY -- REFERENCES -- 5 -- CIRCULATING MIRNAS INCREASING THE RISK OF CANCER -- INTRODUCTION -- HOW CIRCULATING MIRNAS ARE FOUND IN BLOOD SAMPLES -- DISCOVERY OF CIRCULATING MIRNA -- EXTRACELLULAR MIRNA -- WHY CIRCULATING MIRNAS ARE BECOMING AN INCREASING RISK CIRCULATING MIRNA IS ABLE TO SHUTTLE BETWEEN DIFFERENT CELLSSECRETED MIRNAS CAN SERVE AS SIGNALING MOLECULES MEDIATING INTERCELLULAR COMMUNICATION -- CIRCULATING MIRNAS CAN BE USED AS AN EARLY DETECTION TECHNIQUE -- THE DIAGNOSTIC POTENTIAL OF MIRNAS IN VARIOUS CANCERS -- Lung Cancer -- Breast Cancer -- Colorectal Cancer -- Gastric Cancer -- Other Cancers -- CHALLENGES IN UTILIZING MIRNAS AS CIRCULATING BIOMARKERS -- THE THERAPEUTIC IMPLICATIONS OF MIRNAS -- CONCLUSION AND FUTURE PERSPECTIVES -- REFERENCES -- 6 -- LONG NONCODING RNAS AS CANCER BIOMARKERS ""INTRODUCTION: â#x80;#x9C;JUNK DNA, â#x80;#x9D; THE NEW KEY PLAYER IN DEVELOPMENT AND DISEASE"" Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (EBSCO, viewed October 18, 2017) Subject Non-coding RNA. Cancer -- Genetic aspects. RNA, Untranslated SCIENCE -- Life Sciences -- Biochemistry. Cancer -- Genetic aspects Non-coding RNA Form Electronic book Author Chakrabarti, Jayprokas, editor. Mitra, Sanga, editor ISBN 9780128134375 0128134372

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