| Description |
1 online resource (xv, 286 pages) : illustrations |
| Contents |
Structural analysis of toll-like receptors / by Jungwoo Choe and Ian A. Wilson -- Antiviral signaling through TLRs and RLHs / by Taro Kawai -- Recognition of virus invasion by toll-like receptors and RIG-I-like helicases / by Hiroki Kato and Osamu Takeuchi -- Characteristics of dendritic cell responses to nucleic acids / by Tsuneyasu Kaisho, Takahiro Sugiyama, and Katsuaki Hoshino -- Dendritic cells as sensors for foreign and self nucleic acids / by Anne Krug and Wolfgang Reindl -- Natural DNA recognition by toll-like receptor 9 does not reply upon CpG motifs: role of endosomal compartmentation / by Tobias Haas [and others] -- Discrimination of self and non-self DNA / by Katryn J. Stacey [and others] -- Therapeutic potential of immunosuppressive oligonucleotides expressing TTAGGG motifs / by Dennis M. Klinman [and others] -- Structure/function of IFN?-inducing CpG ODN / by Daniela Verthelyi and Montserrat Puig |
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Clinical development of oligodeoxynucleotide TLR9 agonists / by Julie L. Himes and Arthur M. Krieg -- Prospects for TLR9- based immunotherapy for asthma and allergy / by David Broide -- Toll-like receptors in the development of systemic autoimmune disease : in vitro artifact or in vivo paradigm? / by Ann Rothstein -- Impacts of nucleoside modification on RNA-mediated activation of toll-like receptors / by Katalin Karikó and Drew Weissman -- Activation of innate pattern recognition pathways by single-stranded ribonucleic acids / by Sandra Diebold -- RNA interference in scope of immune system / by Andrea Ablasser, Gunther Hartmann, and Veit Hornung -- Recognition of RNA and synthetic compounds by TLR7 and TLR8 / by Svetlana Hamm and Stefan Bauer -- Helicases at frontline of RNA virus recognition / by Leonid Gitlin and Marco Colonna |
| Summary |
Offering insight into areas of immunology, this book explains the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs). It discusses how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Natural immunity.
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Nucleic acids.
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Autoimmunity.
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Immunity, Innate -- physiology
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Immunity, Innate
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Autoimmunity
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DNA -- immunology
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RNA -- immunology
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Receptors, Pattern Recognition -- immunology
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Self Tolerance
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MEDICAL -- Immunology.
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Autoimmunity
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Natural immunity
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Nucleic acids
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Angeborene Immunität
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Immunreaktion
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Nucleinsäuren
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| Genre/Form |
Aufsatzsammlung.
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| Form |
Electronic book
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| Author |
Ishii, Ken J
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Akira, S
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| ISBN |
9781420068269 |
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1420068261 |
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9780429149870 |
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0429149875 |
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