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Book Cover
Author Ehlert, Frederick J., author.

Title Affinity and efficacy : the components of drug-receptor interactions / Frederick J. Ehlert
Published New Jersey : World Scientific, [2014]


Description 1 online resource
Contents Ligand-gated ion channels -- Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- Competitive interactions between orthostheric ligands at ligand-gated ion channels -- Analysis of allosteric interactions at ligand-gated ion channels -- G protein-coupled receptors and G protein signaling -- Affinity and efficacy of the agonist-receptor-G-protein interaction -- Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- Analysis of ligand bias in receptor signaling through different G protein pathways -- Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- Analysis of allosterism in functional assays on G protein-coupled receptors -- Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors
Bibliography Includes bibliographical references
Notes Print version record
Subject Drug receptors.
Drugs -- Effectiveness.
Drug-nutrient interactions.
Pharmaceutical chemistry.
Carrier proteins.
Radioligand assay.
Receptors, Drug
Food-Drug Interactions
Chemistry, Pharmaceutical
Ligand-Gated Ion Channels
Carrier Proteins
Radioligand Assay
Receptors, G-Protein-Coupled
MEDICAL -- Pharmacology.
Radioligand assay
Carrier proteins
Drug-nutrient interactions
Drug receptors
Drugs -- Effectiveness
Pharmaceutical chemistry
Form Electronic book
ISBN 9789814324229
Other Titles Components of drug-receptor interactions