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Book Cover
Author Patel, Harun M., author

Title Third-Generation EGFR Inhibitors : Overcoming EGFR Resistance and Toxicity Problems / Harun M. Patel, Rahul Pawara, Sanjay J. Surana
Edition First edition
Published Amsterdam : Elsevier, [2019]


Description 1 online resource
Summary Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed December 5, 2018)
Subject Epidermal growth factor -- Receptors -- Testing
Epidermal growth factor -- Receptors -- Inhibitors
Protein-tyrosine kinase -- Inhibitors -- Therapeutic use
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Form Electronic book
Author Pawara, Rahul, author
Surana, Sanjay J., author
ISBN 9780081026625
Other Titles Third-generation epidermal growth factor receptor inhibitors