| Description |
1 online resource |
| Contents |
Front Cover; Adenosine Receptors in Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Foreword and History of Adenosine in the Central Nervous System; References; Acknowledgments; I. Physiology; 1 Adenosine Receptor Biology in the Central Nervous System; Sources of Adenosine in the CNS; Receptor Subtypes and Their CNS Distribution; A1 Adenosine Receptors; A2A Adenosine Receptors; A2B Adenosine Receptors; A3 Adenosine Receptors; Crosstalk With Other Receptors; Adenosine and CNS Diseases; Recent Clinical Trials; A1 Adenosine Receptors |
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A2A Adenosine ReceptorsA2B Adenosine Receptors; A3 Adenosine Receptors; References; 2 Adenosine Signaling Throughout Development; Introduction; Effects of Adenosine Signaling and Its Dysfunction in CNS; Effects of Adenosine in Oligodendrocytes Development; Effects of Adenosine on Cardiovascular System During Embryogenesis; Postnatal Effects of Adenosine on Cardiovascular System; Postnatal Effect of Adenosine on Respiratory System; Use of Methylxanthines in Premature Babies; Postnatal Effects of Adenosine on the Genitourinary System; Postnatal Effect of Adenosine on the Enteric System |
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Postnatal Effect of Adenosine on Other SystemsConclusion; References; 3 Influence of Adenosine on Synaptic Excitability; Introduction; Molecular & Physiological Mechanisms; Influence on Neurotransmitter Availability and Basal Synaptic Transmission; Adenosine Tunes the Responses of Postsynaptic Glutamate and GABA Receptors; Astrocyte-Derived Adenosine Controls Basal Synaptic Transmission and the Available Range for Plasticity Control; Metamodulation by Adenosine: Impact on Synaptic Plasticity; Adenosine Shapes Synapses for Plasticity; Implications for Epilepsy; Pathophysiological Mechanisms |
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Adenosine Receptor-Dependent EffectsAdenosine Receptor-Independent Effects; Disruption of Adenosine Homeostasis in Epilepsy; Comorbidities of Epilepsy; Therapeutic Implications; Conclusions and Outlook; Acknowledgments; References; 4 Regulation of Synaptic Transmission by Adenosine at the Neuromuscular Junction; Introduction; Neuromuscular Junction; Structural Organization of the Neuromuscular Junction; Neuromuscular Transmission; Coexistence of Transmitters and Neuromodulators; Adenosine as a Neuromodulator at the Neuromuscular Junction |
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Pathways: Synthesis and Degradation of Adenosine at the Neuromuscular JunctionAdenosine Receptors; Nerve Terminals; Schwann Cells; Adenosine Receptors and Their Interactions With Other Receptors at the Neuromuscular Junction; Crosstalk Between A1 and A2A Receptors; Crosstalk Between Adenosine Receptors and Acetylcholine Receptors; Adenosine Receptors and BDNF Actions; Adenosine Signaling in Ageing and Disease; Conclusions; References; 5 Gene Regulation of Adenosine A2A Receptors in the Central Nervous System; General Introduction; A2AR Promoter and Gene Structure; Epigenetics of ADORA2A |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed March 22, 2017) |
| Subject |
Adenosine -- Receptors
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Nervous system -- Degeneration -- Molecular aspects
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Adenosine.
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Receptors, Purinergic P1
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Adenosine
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Neurodegenerative Diseases
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Receptor, Adenosine A2A
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SCIENCE -- Life Sciences -- Biochemistry.
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Adenosine
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Adenosine -- Receptors
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Nervous system -- Degeneration -- Molecular aspects
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| Genre/Form |
Computer network resources
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| Form |
Electronic book
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| Author |
Blum, David, editor
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Lopes, Luísa V., editor
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| ISBN |
9780128037454 |
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0128037458 |
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