| Description |
1 online resource (viii, 464 pages) : illustrations (some color) |
| Contents |
Introduction. Transforming growth factor-[beta] signaling / Carl-Henrik Heldin -- TGF-[beta] signaling in stem cell fate determination / Zhongwei Li, Danny Huylebroeck, Ye-Guang Chen -- Emerging roles of TGF-[beta] co-receptors in human disease / Alison E. Meyer, Karthikeyan Mythreye, Gerard C. Blobe -- Cancer, fibrosis, and inflammation. TGF-[beta] in cancer stem cells / Hiroaki Ikushima, Kohei Miyazono -- TGF-[beta] as tumor suppressor: in vitro mechanistic aspects of growth inhibition / Laurent Bartholin, David F. Vincent, Ulrich Valcourt -- TGF-[beta] as tumor suppressor: lessons from mouse models / Ulrich Valcourt, David F. Vincent, Laurent Bartholin -- The multifunctional roles of TGF-[beta] in navigating the metastatic cascade / Michael K. Wendt, William P. Schiemann -- TGF-[beta] signaling in leukemogenesis / Kazuhito Naka, Atsushi Hirao -- TGF-[beta] in skin cancer and fibrosis / Gangwen Han, Zheyi Han, Xiao-Jing Wang -- The role of TGF-[beta] in cutaneous melanoma biology / Delphine Javelaud, Alain Mauviel -- The transforming growth factor-beta (TGF-[beta]) in liver fibrosis / Isabel Fabregat, Patricia Sancho -- TGF-[beta] and inhibitory smads in inflammation / Seong-Jin Kim, Seok Hee Park -- Cardiovascular diseases. TGF-[beta] and cardiovascular disorders / Laurens A. van Meeteren, Marie-José Goumans, Peter ten Dijke -- TGF-[beta] signaling in physiological and pathological angiogenesis / Sara I. Cunha, Kristian Pietras -- TGF-[beta] signaling pathway and micrornas in cardiovascular disease / Nisha Marathe, Akiko Hata -- Other diseases. TGF-[beta] and genetic skeletal diseases / Shiro Ikegawa, Mitsuko Nakashima, Naomichi Matsumoto -- TGF-[beta] in brain disorders / Kerstin Krieglstein -- TGF-[beta] and metabolic homeostasis / Grace Bennett, Sushil G. Rane -- Disease prognosis and therapy. Targeting pro-angiogenic TGF-[beta] signaling in the tumor microenvironment / Kristian Pietras, Sara I. Cunha |
| Summary |
"Transforming growth factor-[beta] (TGF-[beta]) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-[beta] now is rather well understood. Continuing revelations in the mechanisms of action of TGF-[beta] provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-[beta] pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-[beta] is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-[beta] action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-[beta] field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-[beta] biology is disseminated to the world of science and to the public"--Publisher's description |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from resource home page (SpringerLink, viewed October 21, 2015) |
| Subject |
Transforming growth factors-beta.
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Cell proliferation.
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Cell differentiation.
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Cellular signal transduction.
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Transforming Growth Factor beta
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Cell Transformation, Neoplastic
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Receptors, Transforming Growth Factor beta
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Signal Transduction
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Smad Proteins -- metabolism
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Cell Differentiation
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SCIENCE -- Life Sciences -- Biochemistry.
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Cellular signal transduction
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Cell differentiation
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Cell proliferation
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Transforming growth factors-beta
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| Form |
Electronic book
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| Author |
Moustakas, Aristidis, editor.
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Miyazawa, Keiji, editor.
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| ISBN |
9784431544098 |
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4431544097 |
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