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Title Retrovirus-Cell Interactions / edited by Leslie J. Parent
Published London, United Kingdom ; San Diego, CA, United States : Academic Press is an imprint of Elsevier, [2018]


Description 1 online resource
Contents 880-01 The TriggersConserved Motifs in Envelope Proteins Are Critical to Regulation of Fusion; Regulation by Control of the Conformation of Surface Subunit; Regulation by Control of Disulfide Bond Isomerization and Surface Subunit Conformation; Lentiviruses: Receptor-Triggered Conformational Changes in the Surface Subunit; Gammaretroviruses: Receptor- and Cellular Protease-Driven Disulfide Bond Isomerization; Alpharetroviruses: Receptor- and Low pH-Driven Disulfide Bond Isomerization; DO ENV-RECEPTOR INTERACTIONS CONTRIBUTE TO PATHOGENESIS?; CD4+ T-Cell Depletion and AIDS
880-01/(S TRIM-Cyp: Evolution of a Restriction Factor by Gene Fusion Mov10; Lv2: An Entry-Specific Block; APOBECs, the Cytidine Deaminases; SAMHD1, a Nucleotidase; MX2, Another Factor Targeting Capsid; SUN2; More Restriction Factors; SENSING AND RESPONDING TO INFECTION: INNATE IMMUNITY; TRIM5α as Sensor; RIG-I and MDA5 as Retroviral Sensors; cGAS Involvement in Sensing Infection; IFI16, a DNA Sensor; TREX1, a Nuclease; APPLICATIONS FOR THERAPY; CONCLUSIONS: PARTING WORDS; REFERENCES; 3 -- Nucleoporins in Retroviral Replication: What's Nup Got to Do with It
Neurological Damage and HAM/TSPMutations That Adapt Virus to Low Receptor Levels Can Also Increase Pathogenicity; Envelope Protein-Driven Neoplasia in Betaretrovirus Infection; HOST DEFENSES THAT INHIBIT RETROVIRAL ENTRY ALSO DRIVE ENVELOPE PROTEIN VARIATION; Challenges in Vaccine Development; Interferon-Induced Transmembrane Proteins and Envelope Proteins Variation; COEVOLUTION OF VIRUS AND RECEPTOR; CAPTURED RETROVIRAL ENVELOPE PROTEINS IN THE DEVELOPMENT OF MAMMALIAN PLACENTA AND MALE MUSCLE MASS; REFERENCES; 2 -- Cellular Factors That Regulate Retrovirus Uncoating and Reverse Transcription
Summary Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics features important commonalities and differences among retroviral systems
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (viewed on September 19, 2018)
Subject Retrovirus infections.
Retroviridae Infections -- virology
Retroviridae -- physiology
Host-Pathogen Interactions
Virus Replication -- physiology
Retroviridae Infections
MEDICAL -- Forensic Medicine.
MEDICAL -- Preventive Medicine.
MEDICAL -- Public Health.
Retrovirus infections
Form Electronic book
Author Parent, Leslie J., editor
ISBN 9780128111932