| Description |
1 online resource (xxii, 490 pages) : illustrations (some color) |
| Contents |
Intro; Foreword; Contents; List of Contributors; About the Editors; Part I: Introductory Chapters; 1: The Microbiome: Past, Present, and Future; Past: Surprising Insights into Today's Microbial World; Present: "Democratization of Metagenomics"; Future: Microbiota-Based Therapeutics or Prevention; References; 2: Methods for Microbiota Analysis: Sample Collection and Laboratory Methods; Introduction; Microbiota Research: From Culture- to Molecular-Based Methods; High-Throughput Sequencing of 16S rRNA Genes and Whole Community Profiling; Beyond the 16S rRNA High-ƯThroughput Sequencing |
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Quantitative PCRCloning of the 16S rRNA Genes; Microbiota Array; Staining-, Histology-, and Microscopy-Based Methods; Electrophoresis-Based Methods; Flow Cytometry (FCM); Single-Cell Approaches; Combination of Various Methods in Microbiota Studies; Sample Collection and Sampling Strategies in Microbiota Studies; Sample Collection; Choice and Consequences of the Sampling Method on a Microbiota Study; Additional Sources of Variability and Sampling Design; References; 3: Analytic Methods in Microbiome Studies; Universal Marker; Sequence Preprocessing and OTU Binning; Merging and Trimming |
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Chimera Detection and DenoisingOTU Binning; Classification, Taxonomic Assignment, and Phylogenetic Inference; Phylogenetic Inferences; Diversity Analysis; Alpha and Beta Diversity; Comparing Samples Using Diversity Estimates; Correlating Species with Habitats; Indicator Species Analysis; Differential Abundance (DA) Analysis Based on Count Data; Network Analysis of Co-occurrence/Co-abundance Relationships; Functional Imputation of Amplicon Data; References; Part II: Immunogenetics of the Host Response to Infection; 4: Immunodeficiency and Autoimmunity; Introduction |
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Autoimmunity due to Quantitative T Cell DefectsDeficiency in Development of Central Tolerance due to Defects in Thymic Education; Autoimmunity due to Defects in Treg Development; Autoimmunity by Haploinsufficiency of Immunoregulatory Genes; Autoimmunity from Dominant Gain-of-Function (GOF) Mutations; Autoimmunity with Selective B Cell Deficiencies; Summary; References; 5: Immunology of the Microbiome: Implications for Rheumatoid Arthritis and Other Autoimmune Diseases; Background; Innate Recognition of the Microbiota; Interaction of Adaptive Immunity with the Microbiota |
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Implications for Etiology of RAConcluding Remarks: The Implicated Immunological Mechanisms; References; 6: Animal Models of Rheumatoid Arthritis; Introduction; History of Animal Models of RA; Animal Models of RA; Adjuvant-Induced Arthritis in the Rat; Collagen-Induced Arthritis in the Rat and Mouse; Antigen and/or Antibody-Induced Arthritis Models; Genetically Modified Models of Spontaneous Arthritis; Animal Models Exploring the Role of Microbe-Induced Inflammation in RA; Conclusions: Translating Animal Work to Human Disease; References; Part III: Infectious Agents |
| Summary |
This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed June 29, 2018) |
| Subject |
Rheumatism -- Microbiology
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Communicable diseases.
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Microbiology.
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Rheumatic Diseases -- etiology
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Communicable Diseases
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Microbiology
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microbiology.
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Infectious & contagious diseases.
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Paediatric medicine.
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Rheumatology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Medicine
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Pediatrics
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Rheumatology
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| Form |
Electronic book
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| Author |
Ragab, Gaafar, editor.
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Atkinson, T. Prescott (Thomas Prescott), editor.
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Stoll, Matthew L., editor.
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| ISBN |
9783319790268 |
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3319790269 |
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