| Description |
1 online resource (xix, 670 pages) : illustrations (some color) |
| Contents |
Escherichia Coli Ribonucleases: Paradigms for Understanding Cellular RNA Metabolism and Regulation. Barstar and Barnase. Rnase T1/Rnase T2 Family Rnases. Structures and Mechanism of Action of Cytotoxic Ribonuclease I-Sarcin. Plant Ribonucleases. S-Rnases and Other Plant Extracellular Ribonucleases. Evolutionary Reconstructions in the Ribonuclease Family. Evolution of Vertebrate Ribonucleases: Ribonuclease a Superfamily. Pancreatic Ribonucleases. Crystallographic Studies of Ribonuclease Complexes. NMR Solution Structures of Ribonuclease a and Its Complexes with Mono- And Dinucleotides. Seminal Ribonuclease: The Importance of Diversity. Eosinophil-Associated Ribonucleases. Structure and Function of Angiogenin. Antitumor Rnases. 2-5A-Dependent Rnase L: A Regulated Endoribonuclease in the Interferon System. RNA Processing Rnases in Mammalian Cells. Messenger RNA Ribonucleases and Mrna Turnover in Saccharomyces Cerevisae. Ribonuclease Inhibitor. Subject Index |
| Summary |
Pancreatic ribonuclease, the focus of highly productive scientific research for more than half a century and the only enzyme to be the basis of four Nobel prizes, has recently undergone a resurgence in popularity for the recognition of an extended ribonuclease superfamily with functions ranging from tumour growth and inhibition to self-recognition and neurotoxicity. This volume highlights the functional diversity of ribonucleases and reveals the emerging research opportunities provided by these enzymes. * Never before has discussion of the entire family of ribonucleases and related enzymes been covered in a single volume * Core chapters focus on the latest structures and functions of pancreatic-type ribonucleases * Structures and functions of intracellular ribonucleases and nondigestive members of the family are also covered * How ribonucleases continue to serve as excellent systems with which to uncover the secrets of protein chemistry is demonstrated |
| Analysis |
ribonucleasen |
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ribonucleases |
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chemische structuur |
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chemical structure |
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moleculaire structuur |
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molecular conformation |
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kristallografie |
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crystallography |
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kernmagnetische resonantiespectroscopie |
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nuclear magnetic resonance spectroscopy |
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Proteins and Enzymes |
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Eiwitten en enzymen |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Ribonucleases -- Structure-activity relationships
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Ribonucleases.
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Structure-activity relationships (Biochemistry)
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Ribonucleases
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Structure-Activity Relationship
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SCIENCE -- Life Sciences -- Cell Biology.
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Ribonucleases
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Structure-activity relationships (Biochemistry)
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Ribonucleasen
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Ribonucleasen.
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| Form |
Electronic book
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| Author |
D'Alessio, Giuseppe
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Riordan, James F., 1934-
|
| ISBN |
9780125889452 |
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0125889453 |
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9780080540597 |
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0080540597 |
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