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Title Ryanodine receptors : structure, function and dysfunction in clinical disease / edited by Xander H.T. Wehrens and Andrew R. Marks
Published New York : Springer, ©2005


Description 1 online resource (xxi, 330 pages) : illustrations (some color)
Series Developments in cardiovascular medicine ; v. 254
Developments in cardiovascular medicine ; v. 254.
Contents Evolution of the ryanodine receptor gene family -- Topology and transmembrane organization of ryanodine receptors -- Three-dimensional reconstruction of ryanodine receptors -- RYR-DHPR relationships in skeletal and cardiac muscles -- The pore of the ryanodine receptor channel -- Intra-molecular domain-domain interaction: a key mechanism for calcium channel regulation of ryanodine receptors -- Regulation of sarcoplasmic reticulum calcium release by luminal calcium -- Cytosolic calcium regulation of single ryanodine receptor -- Elementary Ca2+ release events: ryanodine receptor Ca2+ sparks -- Ca2+ release from the sarcoplasmic reticulum in intact cardiomyocytes -- Stability and instability of Ca2+ release from the SR -- Ryanodine receptors in smooth muscle -- Functions of RYR3 homologues -- Knockout mice lacking RYR and junctophilin subtypes -- Regulation of ryanodine receptor Ca2+ release by macromolecular complexes -- RYR1 modulation by calmodulin: effects of protein-protein interaction and redox modification -- Ryanodine receptor function in inflammation -- Ryanoids, receptor affinity and RYR channel subconductance: why the discordance? -- Scorpion peptides as high-affinity probes of ryanodine receptor function -- Redox sensing by the ryanodine receptors -- Ryanodine receptor dysfunction in the diabetic heart -- Molecular and clinical genetics of RYR1 disorders -- Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor -- The dantrolene binding site on RYR1 -- Ryanodine receptor dysfunction in heart failure and arrhythmias -- Stabilization of ryanodine receptor as a novel therapeutic strategy against heart failure -- Ryanodine receptor antibodies and myasthenia gravis
Summary "In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor."--Jacket
Bibliography Includes bibliographical references (pages 281-311) and index
Notes Print version record
In Springer e-books
Subject Ryanodine -- Receptors.
Ryanodine Receptor Calcium Release Channel -- physiology
Ryanodine Receptor Calcium Release Channel -- chemistry
MEDICAL -- Nutrition.
Ryanodine Receptor Calcium Release Channel -- physiology.
Ryanodine Receptor Calcium Release Channel -- chemistry.
Ryanodine -- Receptors.
Ryanodine -- Receptors.
Form Electronic book
Author Wehrens, Xander H. T.
Marks, Andrew R., 1955-
LC no. 2004058942
ISBN 0387231889