| Description |
1 online resource (135 pages) |
| Contents |
880-01 Intro -- Contents -- Chapter 1: History of Sialic Acids, Gangliosides, and GM3 -- References -- Chapter 2: Synthesis of GM3 -- Chapter 3: Molecular Localization of GM3 in Cells -- References -- Chapter 4: Basic Function of GM3 as an Interacting Molecule -- References -- Chapter 5: GD3 Mimetics with a Neurite Forming Capacity -- 5.1 GD3 Mimetic of Deuterostome Echinoderms -- 5.2 GM4-Type and Hematoside-Type Ganglioside Show Immune-Modulating Capacities -- References -- Chapter 6: GM3 as a Pathogenic Infection Receptor -- References |
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880-01/(S 22.3 GM3 Role in a Megakaryocytoid Differentiation Inducer of Human Leukemic K562 Cells -- 22.4 GM3 Is an Inducing Factor of Megakaryocytic Differentiation by CAPE in the Human CML K562 Cells -- References -- Chapter 23: α2,3-Sialyllactose (3SL) or α2,6-Sialyllactose (6SL) of GM3 Glycan in Innate Immunity -- 23.1 3SL/6SL and Gangliosides in Innate Immunity -- 23.2 3SL Interaction with Toll-Like Receptor (TLR)-4 on DCs in Intestinal Innate Immunity -- 23.3 3SL Stimulates CD40, CD80, and CD86 Expression and Driving CD11c+, Ly-6Chi, CD4+, Th-1, and Th-17T Cells with Secreted TN .. |
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Chapter 7: GM3 and Related Gangliosides Prevent Inflammation and Atherosclerosis -- References -- Chapter 8: GM3 Has an Anti-tumor Capacity -- References -- Chapter 9: GM3 Suppresses Tumor Angiogenesis -- References -- Chapter 10: Interaction Between EGFR and GM3 -- References -- Chapter 11: Membrane Ganglioside-Specific Neuraminidase 3 (NEU3) Regulates GM3 Signaling -- References -- Chapter 12: Regulation of GM3-Mediated EGFR Signaling by NEU3 Sialidase -- References -- Chapter 13: VEGFR-GM3 Interaction in Angiogenesis -- 13.1 Soluble sFLT1 Directly Recognize GM3 Embedded in the Lipid Rafts |
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Chapter 18: GM3, Caveolin-1 and Insulin Receptor in Insulin Resistance -- References -- Chapter 19: GM3 Suppresses Arthritis -- References -- Chapter 20: GM3 Protects Cochlear Hair Cells and Hearing from Corti Degeneration -- References -- Chapter 21: GM3 Increases Osteoclast Differentiation Via Direct Cooperation with RANKL and IGF-1 -- References -- Chapter 22: GM3 Induces Terminal Differentiation of Leukemic Cells -- 22.1 GM3 Differentiation Role in Human Leukemic Monocyte Model: THP-1 Cell -- 22.2 GM3 Roles in Both Monocytoid and Granulocytoid Differentiation of HL-60 Cells |
| Summary |
This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field |
| Notes |
23.4 6SL Restores Sialylation of GNE-Related Myopathy |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Gangliosides.
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Gangliosides
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Oncology.
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Genetics (non-medical)
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Biochemistry.
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Cellular biology (cytology)
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Medical genetics.
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Medical -- Oncology.
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Science -- Life Sciences -- Genetics & Genomics.
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Science -- Life Sciences -- Biochemistry.
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Science -- Life Sciences -- Cytology.
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Medical -- Genetics.
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Gangliosides
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| Form |
Electronic book
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| ISBN |
9789811556524 |
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9811556520 |
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