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Title The sarcomere and skeletal muscle disease / edited by Nigel G. Laing
Published New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2008

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Description 1 online resource (xxii, 227 pages) : illustrations (some color)
Series Advances in experimental medicine and biology ; v. 642
Advances in experimental medicine and biology ; v. 642.
Contents 880-01 The sarcomere and sarcomerogenesis / Elisabeth Ehler and Mathias Gautel -- Skeletal muscle alpha-actin diseases / Kathryn N. North and Nigel G. Laing -- Nebulin : a giant chameleon / Katarina Pelin and Carina Wallgren-Pettersson -- Skeletal muscle disease due to mutations in tropomyosin, troponin and cofilin / Nigel F. Clarke -- Investigations into the pathobiology of thin-filament myopathies / Biljana Ilkovski -- Mouse models for thin filament disease / Mai-Anh T. Nguyen and Edna C. Hardeman -- Thick filament diseases / Anders Oldfors and Phillipa J. Lamont -- Acute quadriplegic myopathy : an acquired "myosinopathy" / Lars Larsson -- Third filament diseases / Bjarne Udd -- The Z-disk diseases / Duygu Selcen and Olli Carpén -- Intermediate filament diseases : desminopathy / Lev G. Goldfarb [and others] -- Muscular integrity : a matter of interlinking distinct structures via plectin / Patryk Konieczny and Gerhard Wiche -- The sarcomere and the nucleus : functional links to hypertrophy, atrophy and sarcopenia / Mathias Gautel -- Other model organisms for sarcomeric muscle diseases / John Sparrow, Simon M. Hughes and Laurent Segalat -- Therapeutic approaches for the sarcomeric protein diseases / Kristen J. Nowak
880-01/(Q The sarcomere and sarcomerogenesis / Elisabeth Ehler and Mathias Gautel -- Skeletal muscle alpha-actin diseases / Kathryn N. North and Nigel G. Laing -- Nebulin : a giant chameleon / Katarina Pelin and Carina Wallgren-Pettersson -- Skeletal muscle disease due to mutations in tropomyosin, troponin and cofilin / Nigel F. Clarke -- Investigations into the pathobiology of thin-filament myopathies / Biljana Ilkovski -- Mouse models for thin filament disease / Mai-Anh T. Nguyen and Edna C. Hardeman -- Thick filament diseases / Anders Oldfors and Phillipa J. Lamont -- Acute quadriplegic myopathy : an acquired "myosinopathy" / Lars Larsson -- Third filament diseases / Bjarne Udd -- The Z-disk diseases / Duygu Selcen and Olli Carpe⁺ѓn -- Intermediate filament diseases : desminopathy / Lev G. Goldfarb [and others] -- Muscular integrity : a matter of interlinking distinct structures via plectin / Patryk Konieczny and Gerhard Wiche -- The sarcomere and the nucleus : functional links to hypertrophy, atrophy and sarcopenia / Mathias Gautel -- Other model organisms for sarcomeric muscle diseases / John Sparrow, Simon M. Hughes and Laurent Segalat -- Therapeutic approaches for the sarcomeric protein diseases / Kristen J. Nowak
Summary Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options
Bibliography Includes bibliographical references and index
Subject Muscles -- Diseases.
Muscular Diseases
Muscle, Skeletal -- physiopathology
Sarcomeres
MEDICAL -- Orthopedics.
HEALTH & FITNESS -- Diseases -- Musculoskeletal.
MEDICAL -- Rheumatology.
Muscular Diseases.
Muscle, Skeletal -- physiopathology.
Sarcomeres.
Muscles -- Diseases.
Biomédecine.
Sciences de la vie.
Muscles -- Diseases
Form Electronic book
Author Laing, Nigel G.
ISBN 9780387848464
0387848460
9780387848471
0387848479