| Description |
1 online resource (181 pages) |
| Series |
Pediatric Oncology |
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Pediatric oncology (Series)
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| Contents |
Intro -- Contents -- 1: Epidemiology of Bone and Soft Tissue Sarcomas -- 1.1 Introduction -- 1.2 Descriptive Epidemiology -- 1.2.1 Osteosarcoma -- 1.2.2 Ewing Sarcoma -- 1.2.3 Rhabdomyosarcoma (RMS) -- 1.2.4 Non-rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) -- 1.3 Environmental (Non-genetic) Risk Factors -- 1.3.1 Osteosarcoma -- 1.3.1.1 Growth and Development -- 1.3.1.2 Exogenous Exposures -- 1.3.2 Ewing Sarcoma -- 1.3.3 RMS -- 1.3.4 NRSTS -- 1.4 Germline Genetic Risk Factors -- 1.4.1 Osteosarcoma -- 1.4.2 Ewing Sarcoma -- 1.4.3 RMS -- 1.4.4 NRSTS -- 1.5 Conclusion |
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2.3.1 Pathology -- 2.3.2 Biology -- 2.4 Non-rhabdomyosarcoma Soft Tissue Sarcomas -- 2.4.1 Alveolar Soft Part Sarcoma -- 2.4.1.1 Pathology -- 2.4.1.2 Biology -- 2.4.2 Clear Cell Sarcoma of Soft Tissue -- 2.4.2.1 Pathology -- 2.4.2.2 Biology -- 2.4.3 Desmoid Tumor -- 2.4.3.1 Pathology -- 2.4.3.2 Biology -- 2.4.4 Desmoplastic Small Round Cell Tumor -- 2.4.4.1 Pathology -- 2.4.4.2 Biology -- 2.4.5 Malignant Peripheral Nerve Sheath Tumor -- 2.4.5.1 Pathology -- 2.4.5.2 Biology -- 2.4.6 Synovial Sarcoma -- 2.4.6.1 Pathology -- 2.4.6.2 Biology -- 2.4.7 Malignant Rhabdoid Tumor |
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2.4.7.1 Pathology -- 2.4.7.2 Biology -- 2.4.8 NTRK-Fusion Sarcomas -- 2.4.8.1 Pathology -- 2.4.8.2 Biology -- References -- 3: Staging and Imaging of Sarcoma -- 3.1 Staging of RMS and NRSTS -- 3.2 Staging of Nonrhabdomyosarcomatous Soft Tissue Tumors (NRSTS) -- 3.3 Staging of Bone Sarcomas -- 3.4 Imaging and Staging Procedures -- References -- 4: Multi-institutional Trials for Patients with Rhabdomyosarcoma: Lessons from North American Studies from 1967 Through 1997 -- 4.1 Introduction -- 4.2 The First 30 Years, 1970-2000 -- 4.2.1 The IRS Era, 1972-1997 -- References |
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5: Treatment of Rhabdomyosarcoma -- 5.1 Introduction -- 5.2 Initial Evaluation -- 5.3 Treatment Assignment -- 5.4 Treatment -- 5.4.1 North American Perspective -- 5.4.2 European Perspective -- 5.5 Future Directions -- References -- 6: Current Approaches to Therapy: Soft Tissue Sarcomas Other than Rhabdomyosarcoma in Children and Adolescents -- 6.1 Introduction -- 6.2 Local Therapy -- 6.2.1 Surgery -- 6.2.2 Radiotherapy -- 6.3 Conventional Chemotherapy -- 6.4 Specific Therapy for Diseases -- 6.4.1 Synovial Sarcoma |
| Summary |
This book is a comprehensive and up-to-date compendium on all aspects of sarcomas of bone and soft tissues in childhood and adolescence. After introductory chapters on the history, epidemiology, and biology of pediatric sarcomas, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. The pathology and biology of this diverse group of tumors are extensively reviewed. Promising new treatment approaches are discussed, and strategies for the development of new agents are appraised. The major common pediatric sarcomas, including osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma, are covered in detail. The authors are internationally recognized experts who offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of childhood and adolescent sarcomas and will prove invaluable to specialists, generalists, and trainees alike |
| Bibliography |
References-2: Sarcoma Pathology and Biology-2.1 Rhabdomyosarcoma-2.1.1 Pathology-2.1.1.1 Alveolar Rhabdomyosarcoma-2.1.1.2 Embryonal Rhabdomyosarcoma-2.1.1.3 Spindle Cell/Sclerosing Rhabdomyosarcoma-2.1.2 Biology-2.1.2.1 Fusion-Positive Rhabdomyosarcoma-2.1.2.2 Fusion-Negative Rhabdomyosarcoma-2.1.2.3 Spindle Cell/Sclerosing Rhabdomyosarcoma-2.2 Ewing Sarcoma-2.2.1 Pathology-2.2.2 Biology-2.2.3 Ewing-Like Sarcomas-2.2.3.1 CIC-Rearranged Sarcomas-2.2.3.2 Ewing-Like Sarcoma with BCOR Rearrangements-2.3 Osteosarcoma |
| Notes |
6.4.2 Other "Adult-Type" Sarcomas (Fibrosarcoma, Liposarcoma, Mesenchymal Chondrosarcoma, PECOMA, Leiomyosarcoma, Epithelioid Sarcoma, Clear Cell Sarcoma, Angiosarcoma, Undifferentiated Sarcoma) |
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Print version record |
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Online resource; title from PDF title page (SpringerLink, viewed December 2, 2020) |
| Subject |
Cancer in children.
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Bone -- Cancer
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Soft tissue tumors.
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Bones -- Cancer.
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Sarcoma -- therapy
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Soft Tissue Neoplasms
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Bone Neoplasms
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Soft tissue tumors
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Cancer in children
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Children -- Surgery
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Hematology
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Oncology
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Pathology
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Pediatrics
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| Form |
Electronic book
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| Author |
Arndt, Carola A. S
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| ISBN |
9783030511609 |
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303051160X |
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