| Description |
1 online resource (1 PDF file (x, 65 pages)) : illustrations |
| Series |
Consensus study report |
|
Consensus study report.
|
| Contents |
Introduction -- Approaches to developing exposure values -- Scoping and problem formulation -- Hazard identification -- Quantitative dose-response assessment and derivation of occuational exposure levels -- Conclusions -- Appendixes |
| Summary |
Trichloroethylene (TCE) is a solvent that is used as a degreasing agent, a chemical intermediate in refrigerant manufacture, and a component of spot removers and adhesives. It is produced in mass quantities but creates dangerous vapors and is an environmental contaminant at many industrial and government facilities, including facilities run by the U.S. Department of Defense (DoD). It is important to determine the safe occupational exposure level (OEL) for the solvent in order to protect the health of workers who are exposed to its vapors. However, there are concerns that the current occupational standards insufficiently protect workers from these health threats. Review of DOD's Approach to Deriving an Occupational Exposure Level for Trichloroethylene makes recommendations to improve the DoD's approach to developing an OEL for TCE, strengthen transparency of the process, and improve confidence in the final OEL value. This report reviews the DoD's approach using a literature review, evidence synthesis based on weight of evidence [WOE], point-of-departure derivation, physiologically based pharmacokinetic modeling, extrapolation tools, and explores other elements of the process of deriving an OEL for TCE. It examines scientific approaches to developing exposure values and cancer risk levels, defining the scope of the problem, and improving hazard identification |
| Notes |
"A consensus study report of the National Academies of Sciences, Engineering, and Medicine." |
| Bibliography |
Includes bibliographical references |
| Notes |
This activity was supported by a contract (W81K04-16-D-0036/W81K0418F0055) between the National Academy of Sciences and the U.S. Department of Defense. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project |
|
Description based on online resource; title from PDF title page (viewed June 8, 2020) |
| Subject |
United States. Department of Defense |
|
Trichloroethylene -- Threshold limit values
|
|
Solvents -- Threshold limit values
|
|
Biological exposure indices (Industrial toxicology)
|
|
Threshold limit values (Industrial toxicology)
|
|
Trichloroethylene -- adverse effects
|
|
Solvents -- adverse effects
|
|
Threshold Limit Values
|
|
Maximum Allowable Concentration
|
|
Threshold limit values (Industrial toxicology)
|
|
Biological exposure indices (Industrial toxicology)
|
|
United States |
| Form |
Electronic book
|
| ISBN |
9780309499279 |
|
0309499275 |
|
9780309499255 |
|
0309499259 |
|
