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Title Biology of IGF-1 : its interaction with insulin in health and malignant states / [edited by] Gregory Bock, Jamie Goode
Published Hoboken, N.J. : John Wiley & Sons, 2004
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Description 1 online resource (viii, 280 pages, 4 pages) of plates : illustrations ; cm
Series Novartis Foundation symposium ; 262
Novartis Foundation symposium ; 262
Contents Machine derived contents note: Chair's Introduction (Leroith). -- Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse (Yakar et al). -- Physiology of the IGF system (Holly). -- Molecular basis of insulin action (Zick). -- IGF-1 and insulin as growth hormones (Laron). -- Insulin-like growth factors and neoplasia (Pollak). -- Loss of IGF2 imprinting: mechanisms and consequences (Ohlsson). -- Insulin and IGF-1 receptor trafficking and sginalling (Foti et al). -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb (Nobukini and Thomas). -- Structural biology of insulin and IGF-1 receptors (De Meyts et al). -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy (Adachi et al). -- IGF-1 and prostate cancer (Roberts Jr.). -- IGF-1 and breast cancer (Lonning and Helle). -- IGFBPs and cancer (Fang et al). -- The IGF receptor as anti-cancer treatment target (Macaulay). -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence (Kaaks). -- Final discussion. -- Index of contributors. -- Subject index
Analysis Chemical Biology and Biochemistry
ER Internet Book Full text
FACsci
Bibliography Includes bibliographical references and index
Subject Carcinogenesis -- Congresses.
Somatomedin -- Pathophysiology -- Congresses.
Somatomedin -- Physiological effect -- Congresses.
Genre/Form Conference papers and proceedings.
Form Electronic book
Author Bock, Gregory.
Goode, Jamie.
John Wiley & Sons.
Wiley InterScience (Online service)
ISBN 0470869976 (electronic bk.)
0470869984 (alk. paper)