Title Somatostatin analogues : from research to clinical practice / edited by Alicja Hubalewska-Dydejczyk, Alberto Signore, Marion de Jong, Rudi A. Dierckx, John Buscombe, Christophe Van de Wiele

Published Hoboken, New Jersey : Wiley, [2015]

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Description 1 online resource Contents Intro -- TITLE PAGE -- TABLE OF CONTENTS -- CONTRIBUTORS -- PREFACE -- ACKNOWLEDGMENTS -- 1 SOMATOSTATIN: THE HISTORY OF DISCOVERY -- REFERENCES -- 2 PHYSIOLOGY OF ENDOGENOUS SOMATOSTATIN FAMILY: SOMATOSTATIN RECEPTOR SUBTYPES, SECRETION, FUNCTION AND REGULATION, AND ORGAN SPECIFIC DISTRIBUTION -- INTRODUCTION -- SECRETION -- ANTIPROLIFERATIVE SIGNALING -- SSTR1 -- SSTR2 -- SSTR3 -- SSTR4 -- SSTR5 -- INDIRECT ANTIPROLIFERATIVE ACTION OF SSTRS -- ORGAN SPECIFIC DISTRIBUTION -- CONCLUSION -- REFERENCES -- 3 SOMATOSTATIN RECEPTORS IN MALIGNANCIES AND OTHER PATHOLOGIES -- PREMISE -- METHODS TO IDENTIFY SSTR IN TISSUES -- SSTR EXPRESSION IN HUMAN MALIGNANCIES -- SSTR EXPRESSION IN NEUROENDOCRINE NEOPLASMS -- SSTR EXPRESSION IN NONNEUROENDOCRINE MALIGNANCIES -- SSTR IN NONNEOPLASTIC DISEASES -- UNMET CLUES -- REFERENCES -- 4 THE USE OF RADIOLABELED SOMATOSTATIN ANALOGUE IN MEDICAL DIAGNOSIS: INTRODUCTION -- REFERENCES -- 4.1 SOMATOSTATIN RECEPTOR SCINTIGRAPHY-SPECT -- RADIOPHARMACEUTICALS FOR SRS-SPECT -- RADIOLABELING OF PEPTIDES FOR SRS-SPECT -- KITS FOR 99mTc-LABELED SOMATOSTATIN ANALOGUES -- MODIFICATIONS OF OCTREOTIDE FOR SPECT-SRS -- DEVELOPMENTS IN SRS-SPECT TRACERS -- CLINICAL UTILITY OF SRS-SPECT IN NEUROENDOCRINE TUMORS -- CONCLUSIONS -- REFERENCES -- 4.2 MOLECULAR IMAGING OF SOMATOSTATIN RECEPTOR-POSITIVE TUMORS USING PET/CT -- INTRODUCTION -- SMS ANALOGUES FOR PET/CT IMAGING -- SSTR PET/CT USING 68Ga -- IMAGING PROTOCOL -- DIAGNOSIS, STAGING, AND RESTAGING -- DETECTION OF UNKNOWN PRIMARY TUMOR -- THERAPY PLANNING -- EVALUATION OF THERAPY RESPONSE AND PROGNOSIS -- SUMMARY -- REFERENCES -- 4.3 OTHER RADIOPHARMACEUTICALS FOR IMAGING GEP-NET -- INTRODUCTION -- CATECHOLAMINE PATHWAY -- SEROTONIN PATHWAY -- CONCLUSION -- REFERENCES -- 4.4 THE PLACE OF SOMATOSTATIN RECEPTOR SCINTIGRAPHY IN CLINICAL SETTING: INTRODUCTION -- REFERENCES 4.4.1 SOMATOSTATIN RECEPTOR SCINTIGRAPHY IN MANAGEMENT OF PATIENTS WITH NEUROENDOCRINE NEOPLASMS -- GASTRIC NEUROENDOCRINE NEOPLASMS -- DUODENAL NEUROENDOCRINE NEOPLASMS -- DIAGNOSTIC PROCEDURES IN ZES -- PANCREATIC NEUROENDOCRINE NEOPLASMS -- FUNCTIONING p-NENS -- BRONCHIAL NENS -- JEJUNOILEAL NENS -- APPENDICEAL NENS -- GCC -- RADIO-GUIDED SURGERY -- COLORECTAL NENS -- NENS OF UNKNOWN ORIGIN -- SUMMARY -- REFERENCES -- 4.4.2 THE PLACE OF SOMATOSTATIN RECEPTOR SCINTIGRAPHY AND OTHER FUNCTIONAL IMAGING MODALITIES IN THE SETTING OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA -- PHEOCHROMOCYTOMAS AND PARAGANGLIOMAS -- FUNCTIONAL IMAGING TARGETS -- SSTR EXPRESSION IN PPGLS -- EXPRESSION OF SSTRS AND IMAGING DIAGNOSTICS OF PPGLS -- SENSITIVITY AND SPECIFICITY OF SRS -- SENSITIVITY OF OTHER FUNCTIONAL IMAGING MODALITIES -- IMAGING ACROSS HEREDITARY SYNDROMES -- CONCLUSIONS -- SUMMARY -- REFERENCES -- 4.4.3 SOMATOSTATIN RECEPTOR SCINTIGRAPHY IN MEDULLARY THYROID CANCER -- INTRODUCTION -- SOMATOSTATIN AS AN IMAGING TOOL IN PATIENTS WITH MTC -- THERAPEUTIC USE OF SOMATOSTATIN ANALOGUES -- REFERENCES -- 4.4.4 SOMATOSTATIN RECEPTOR SCINTIGRAPHY IN OTHER TUMORS IMAGING -- INTRODUCTION -- CENTRAL NERVOUS SYSTEM -- HEAD AND NECK TUMORS -- LUNG -- BREAST -- OTHER CHEST TUMORS -- DIGESTIVE SYSTEM -- UROGENITAL NEOPLASMS -- NEUROBLASTOMA -- MERKEL CELL CARCINOMA -- LYMPHOMA -- TUMOR-INDUCED OSTEOMALACIA (TIO) -- ACKNOWLEDGMENTS -- REFERENCES -- 4.4.5 SOMATOSTATIN RECEPTOR SCINTIGRAPHY IN INFLAMMATION AND INFECTION IMAGING -- INTRODUCTION -- SOMATOSTATIN RECEPTOR EXPRESSION IN INFLAMMATORY DISEASES -- STUDY OF SJÖGREN SYNDROME BY SRS -- STUDY OF THYROID DISEASES BY SRS -- STUDY OF SARCOIDOSIS BY SRS -- STUDY OF IBD BY SRS -- STUDY OF RHEUMATOID ARTHRITIS BY SRS -- CONCLUSIONS -- REFERENCES -- 5 SOMATOSTATIN ANALOGUES IN PHARMACOTHERAPY: INTRODUCTION -- REFERENCES 5.1 SOMATOSTATIN ANALOGUES IN PHARMACOTHERAPY -- REFERENCES -- 5.2 PITUITARY TUMOR TREATMENT WITH SOMATOSTATIN ANALOGUES -- INTRODUCTION -- PITUITARY TUMORS PRODUCING GH: ACROMEGALY -- PITUITARY TUMORS PRODUCING ACTH: CUSHING'S DISEASE -- PITUITARY TUMORS PRODUCING TSH: THYROTROPINOMAS -- PITUITARY TUMORS PRODUCING PRL: PROLACTINOMAS -- NONFUNCTIONING PITUITARY TUMORS -- REFERENCES -- 5.3 SOMATOSTATIN ANALOGUES IN PHARMACOTHERAPY OF GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS -- BIOLOGY -- SYMPTOMATIC EFFECTS -- ANTITUMORAL EFFECT -- WHAT ABOUT NEW SST ANALOGUES? -- CONCLUSIONS -- REFERENCES -- 5.4 SOMATOSTATIN ANALOGUES USE IN OTHER THAN ENDOCRINE TUMOR INDICATIONS -- INTRODUCTION -- SSA USE IN GASTROENTEROLOGY -- SSA USE IN OPHTHALMOLOGY -- SSA USE IN THE TREATMENT OF HYPOGLYCEMIA -- ONCOLOGY -- INFLAMMATORY DISEASES -- REFERENCES -- 6 PEPTIDE RECEPTOR RADIONUCLIDE THERAPY USING RADIOLABELED SOMATOSTATIN ANALOGUES: AN INTRODUCTION -- THE SOIL -- THE PEPTIDES -- SUCCESS AND FAILURE -- DOES IT WORK? -- DOSIMETRY -- WAYS FORWARD? -- CONCLUSIONS -- REFERENCES -- 6.1 SOMATOSTATIN ANALOGUES AND RADIONUCLIDES USED IN THERAPY -- INTRODUCTION -- SOMATOSTATIN ANALOGUES AND CHELATORS -- RADIONUCLIDES USED IN PRRT -- PREREQUISITES FOR THE DESIGN OF RADIOLABELED PEPTIDES -- CLINICAL STUDIES -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 6.2 PRRT DOSIMETRY -- PEPTIDE RECEPTOR RADIONUCLIDE THERAPY -- BONE MARROW TOXICITY AND DOSIMETRY IN PRRT -- KIDNEY TOXICITY IN PRRT -- KIDNEY DOSIMETRY IN PRRT -- LINEAR QUADRATIC MODEL ANDBED -- BONE MARROW DOSIMETRY CONSIDERATIONS -- BONE MARROW RADIATION TOXICITY LITERATURE -- INDUCTION OF MYELODYSPLASTIC SYNDROME AND ACUTE LEUKEMIA -- KIDNEY DOSIMETRY CONSIDERATIONS -- KIDNEY DOSIMETRY: HETEROGENEITY OF THE DOSE DELIVERED TO KIDNEYS -- REFERENCES -- 6.3 PEPTIDE RECEPTOR RADIONUCLIDE THERAPY (PRRT): CLINICAL APPLICATION INTRODUCTION -- RATIONALE -- CLINICAL PROTOCOL -- EFFICACY -- TOLERABILITY -- CONCLUSIONS -- REFERENCES -- 6.4 DUO-PRRT OF NEUROENDOCRINE TUMORS USING CONCURRENT AND SEQUENTIAL ADMINISTRATION OF Y-90- AND LU-177-LABELED SOMATOSTATIN ANALOGUES -- INTRODUCTION -- RADIONUCLIDES -- CONCEPT OF COMBINED PRRT -- INDIVIDUALIZED PRRT -- SUMMARY -- REFERENCES -- 6.5 NONSYSTEMIC TREATMENT OF LIVER METASTASES FROM NEUROENDOCRINE TUMOR -- TRANSARTERIAL PEPTIDE RECEPTOR RADIONUCLIDE THERAPY -- RFA -- SELECTIVE INTERNAL RADIATION THERAPY -- CLINICAL RESULTS OF THE SIRT IN PRIMARY AND SECONDARY HEPATIC MALIGNANCIES -- CONCLUSION -- REFERENCES -- 6.6 PEPTIDE RECEPTOR RADIONUCLIDE THERAPY: OTHER INDICATIONS -- REFERENCES -- 7 SOMATOSTATIN ANALOGS -- NATIVE HORMONES -- SS RECEPTOR SUBTYPES -- EXPRESSION OF SST1-5 IN NORMAL TISSUES AND TUMORS -- FROM SST2 PREFERRING TO PANSOMATOSTATIN RADIOLIGANDS -- REFERENCES -- 8 RADIOLABELED SOMATOSTATIN RECEPTOR ANTAGONISTS -- INTRODUCTION -- RADIOLABELED ANTAGONISTS -- CONCLUSION -- REFERENCES -- 9 CORTISTATINS AND DOPASTATINS -- CST -- DOPASTATIN -- CONCLUSIONS -- REFERENCES -- INDEX -- END USER LICENSE AGREEMENT Summary Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: -Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy -Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic -Focuses on future applications, novel compounds, and areas for further research -Covers topics by authors who are renowned experts and researchers in the field Bibliography Includes bibliographical references and index Notes Print version record and CIP data provided by publisher Subject Somatostatin. Somatostatin -- Therapeutic use Somatostatin -- analogs & derivatives Receptors, Somatostatin -- therapeutic use Somatostatin -- therapeutic use Somatostatin MEDICAL -- Physiology. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. Biochemistry. Diagnostic Imaging. MEDICAL. Clinical. Chemistry. SCIENCE. Life Sciences. Somatostatin Genre/Form Electronic books Form Electronic book Author Hubalewska-Dydejczyk, Alicja, editor. LC no. 2014043305 ISBN 9781119031635 111903163X 9781119031383 1119031389 9781119031659 1119031656 1118521536 9781118521533

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