Chapter 1 Physiology of Somatostatin -- chapter 2 Somatostatin Receptors: Distribution in Normal Tissues and Transduction Mechanisms -- chapter 3 Somatostatin Analogs: Lessons in Functional Complexity and Receptor Interactions -- chapter 4 Somatostatin Receptors in Human Tumors: In Vitro Studies -- chapter 5 The Treatment of Acromegaly with Somatostatin Analogs -- chapter 6 The Treatment of Neuroendocrine Tumors (NET) with Somatostatin Analogs -- chapter 7 Radiolabeled Somatostatin Analogs in the Diagnosis and Therapy of Neuroendocrine Tumors -- chapter 8 Somatostatin Analogs?New Perspectives
Summary
Somatostatin is a peptide isolated originally from the hypothalamus and considered as an inhibitor of growth hormone secretion. However, further studies have shown that the peptide was ubiquitously distributed and exerts a large spectrum of physiological effects, mostly of an inhibitory nature. The very short half-life of the native peptide limits its therapeutic application. To overcome this limitation the long-lasting modified molecules (analogs) of somatostatin were synthesized. The present book provides comprehensive data on the application of somatostatin analogs in diagnostics and treatment of diseases, mostly endocrine disorders and cancers
