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Book Cover
E-book
Author Sun, Xiao-Yu

Title Total synthesis of plakortide E and biomimetic synthesis of plakortone B / Xiao-Yu Sun
Published Berlin ; New York : Springer, ©2012

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Description 1 online resource (xiv, 220 pages) : color illustrations
Series Springer theses
Springer theses.
Contents Introduction -- Results and Discussion -- Conclusion -- Experimental Section -- References -- Appendix I -- Appendix II
Summary In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery
Analysis Chemistry
Biochemistry
Catalysis
Organic Chemistry
Medicinal Chemistry
Notes "Doctoral thesis accepted by The Chinese University of Hong Kong."
Ph. D. Chinese University of Hong Kong
Bibliography Includes bibliographical references
Subject Peroxides -- Synthesis
Stereoisomers -- Synthesis
SCIENCE -- Chemistry -- Organic.
Science des matériaux.
Chimie.
Genre/Form doctoral dissertations.
theses.
dissertations.
masters theses.
Academic theses
Academic theses.
Thèses et écrits académiques.
Form Electronic book
ISBN 9783642271953
3642271952
3642271944
9783642271946