| Description |
1 online resource (116 pages) |
| Contents |
Intro -- Contents -- About the Editors -- Chapter 1: Rodent Stroke Model Guidelines: An Update -- 1.1 Introduction -- 1.2 The General Guideline for a Rodent Model for Stroke -- 1.3 STAIR Committee, Recommendations, and Guidelines -- 1.4 Intraluminal Model -- 1.5 Different Types of the Occluder and their Success Rate -- 1.6 PLL-Coated Occluders -- 1.7 Flame Blunted Occluders -- 1.8 Silicone-Rubber Coated Occluders -- 1.9 An Optimization Technique for Intraluminal Inserting Occluders -- 1.10 Optimization of Surgical Procedure -- 1.11 The Tamura Method of a Stroke Model |
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1.12 Infarction Area Estimation -- 1.13 Methods for Infarction Visualization -- 1.14 Direct Image of Infarction in Fresh Brain Sections Stained with TTC Solution -- 1.15 Digital Method for Defining the Infarction -- 1.16 Calculation of Infarction Volume -- 1.17 Preparation of Stroke Surgical Procedure -- 1.18 Koizumiś Suture Method -- 1.19 Longaś MCAO Method -- 1.20 Neurobehaviour Assessment of Functional Recovery -- 1.21 Assessment of Neurological Functional Outcomes -- 1.21.1 Composite Score -- 1.21.1.1 Bederson Scale and Neurological Deficit Scoring |
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1.21.1.2 Modified Neurological Severity Score -- 1.21.2 Motor Tests -- 1.21.2.1 Cylinder Test -- 1.21.2.2 Ledged Tapered Beam Test -- 1.21.2.3 Pellet Retrieval Task -- 1.21.3 Sensorimotor Test -- 1.21.3.1 Forelimb Flexion -- 1.21.3.2 Forelimb Placing -- 1.21.3.3 Accelerated Rotarod Test -- 1.21.3.4 Adhesive Removal Test -- 1.22 Anesthetics -- 1.23 Monitoring and Maintaining the Core Brain Temperature -- 1.24 Mechanical Ventilation, Blood Gases, Glucose, and Blood Pressure Monitoring -- 1.25 Pilot Study Plan and Implementation of a Preclinical Stroke Trial |
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1.26 Application of the Suitable Statistical Method for Data Analysis -- 1.27 Standard Operating Procedures for Creating a Stroke Model -- 1.28 Conclusion and Future Direction -- References -- Chapter 2: Bilateral Common Carotid Artery Occlusion: Stroke Model -- 2.1 Introduction -- 2.2 Importance of BCCAO -- 2.3 Permanent BCCAO -- 2.4 Transient BCCAO -- 2.5 BCCAO Sham Surgery -- 2.6 Factors Affecting the BCCAO -- 2.6.1 Effect of Ischemic Preconditioning -- 2.7 Effect of ROS -- 2.8 Effect of Mitochondrial Dysfunction -- 2.9 Role of the Apoptotic Pathway |
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2.10 Effect of BCCAO Duration and Animal Model Sex -- 2.11 Effect on Blood-Brain Barrier -- 2.12 Effect of Oxygen Free Radicals -- 2.13 Conclusion -- References -- Chapter 3: Cerebral Venous Sinus Thrombosis Rodent Model -- 3.1 Introduction -- 3.2 Clinical Manifestation, Diagnosis, and Prognosis of CVST -- 3.3 Clinical Recommendation for Management of CVST Patients -- 3.4 Experimental CVST Model Protocol -- 3.5 Precautions -- 3.6 TTC Staining Technique -- 3.7 Neurological Evaluation -- 3.8 CVST as a Preclinical Model for Evaluation of Neuroprotective Agents -- References |
| Summary |
This book summarizes various tools and techniques used to provide insights into the cellular and molecular pathophysiology of stroke. It also presents rodent animal models to help shed light on the pathophysiology of ischemic stroke. Presenting the latest information on the different types of stroke, including embolic, filament, photothrombotic, and bilateral common carotid artery, the book also describes techniques that are used for confirmation of stroke surgery, such as laser speckle imaging (LSI) and laser Doppler flowmetry (LDF), and discusses the non-human primates that are used in stroke surgery, cerebral venous sinuous thrombosis, and neurobehavioral assessment. Lastly, it analyzes various neuroprotective agents to treat and prevent ischemic stroke, and examines the challenges and advances in treating and preventing acute ischemic stroke |
| Notes |
Chapter 4: A Non-human Primate Model for Cerebral Stroke |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed April 22, 2021) |
| Subject |
Cerebrovascular disease -- Simulation methods
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Diseases -- Animal models.
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Stroke -- physiopathology
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Brain Ischemia -- physiopathology
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Disease Models, Animal
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Diseases -- Animal models
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Malalties cerebrovasculars.
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Models biològics.
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Manuals de laboratori.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Tripathi, Amit Kumar.
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Singh, Abhishek Kumar
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| ISBN |
9789813366794 |
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9813366796 |
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9789813366800 |
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981336680X |
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9789813366817 |
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9813366818 |
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