| Description |
1 online resource (xix, 1134 pages) : illustrations (some color) |
| Contents |
Major histocompatibility complex class II -- Genetic susceptibility and class III complement genes -- Constitutive genes and lupus -- Genetics of lupus in mice -- B-cell tolerance and autoimmunity -- Dendritic cells in SLE -- T-cells and systemic lupus erythematosus -- B-lymphocyte biology in SLE -- Polymorphonuclear and endothelial cells -- Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T-cells of patients with SLE -- Cell cycle regulation and systemic lupus erythematosus -- The role of reactive nitrogen and oxygen intermediates in system lupus erythematosus -- Origins of antinuclear antibodies -- Anti-DNA antibodies: structure, regulation and pathogenicity -- Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis -- Antihistone and antispliceosomal antibodies -- Toll-like receptors in SLE -- Interferon-alpha in systemic lupus erythematosus -- Immune complexes in systemic lupus erythematosus -- Complement and tissue injury in SLE -- Humoral pathogenesis: Fc[gamma] receptors in autoimmunity and end-organ damage -- Drug-induced lupus mechanisms -- Gender and age in lupus -- Roles for infections in systemic lupus erythematosus pathogenesis -- Systemic lupus erythematosus in domestic animals -- Pathogenesis of lupus nephritis -- Tissue injury and the skin -- Neuropsychiatric systemic lupus erythematosus: mechanisms of injury -- Atherosclerosis and tissue injury in systemic lupus erythematosus -- The clinical presentation of systemic lupus erythematosus -- Neonatal lupus -- SLE in children -- Drug-induced disease -- Laboratory evaluation of patients with systemic lupus erythematosus -- Pregnancy and reproductive concerns in systemic lupus erythematosus -- Epidemiology of systemic lupus erythematosus -- Monitoring disease activity -- Incomplete lupus erythematosus -- Design of clinical trials for SLE -- The nervous system and lupus -- Skin -- Kidney -- Heart -- Vasculitis -- Lung -- Gastrointestinal: liver -- Gastrointestinal: nonhepatic -- Cellular hematology -- Musculoskeletal system: articular disease, bone metabolism -- Antiphospholipid syndrome: pathogenesis -- Endothelial cell damage and atherosclerosis -- Laboratory testing for antiphospholipid syndrome -- Clinical presentation of antiphospholipid syndrome -- Pregnancy and antiphospholipid syndrome -- Treatment of antiphospholipid syndrome -- Corticosteroid and nonsteroidal anti-inflammatory drug use in systemic lupus erythematosus -- Antimalarials and SLE -- Systemic lupus erythematosus: cytotoxic agents -- Biologic agents in the treatment of systemic lupus erythematosus |
| Summary |
Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Lupus is the prototypic autoimmune disease and Systemic Lupus Erythematosus examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. * Highly illustrated and in full color throughout * Basic science section expanded, allowing the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment * Clinical aspects and new drugs are covered in great detail providing a useful reference to professionals interested in lupus |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Systemic lupus erythematosus.
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Antiphospholipid syndrome.
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Lupus Erythematosus, Systemic
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Antiphospholipid Syndrome
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Lupus Erythematosus, Cutaneous
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HEALTH & FITNESS -- Diseases -- Musculoskeletal.
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MEDICAL -- Orthopedics.
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MEDICAL -- Rheumatology.
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Antiphospholipid syndrome.
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Systemic lupus erythematosus.
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Systemisk lupus erythematosus.
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Autoimmuna sjukdomar.
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Reumatiska sjukdomar.
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| Form |
Electronic book
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| Author |
Lahita, Robert G. (Robert George), 1945-
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| ISBN |
9780123749949 |
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0123749948 |
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9780080961712 |
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0080961711 |
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