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Title Advances in tumor immunology and immunotherapy / Joseph D. Rosenblatt [and others], editors
Published New York : Springer, 2013


Description 1 online resource (369 pages)
Series Current Cancer Research
Current cancer research.
Contents Part I: Immune Activation, Suppression and Manipulation of the Immune Antitumor Response -- Myeloid-Derived Suppressor Cells in Cancer / Christos E. Kyriakopoulos, Alberto J. Montero and Claudia Marcela Diaz-Montero -- The Role of B Cells in Shaping the Antitumor Immune Response / Yu Zhang, Taylor H. Schreiber and Joseph D. Rosenblatt -- Heat-Shock Protein-Based Cancer Immunotherapy / Taylor H. Schreiber -- Activation of NK Cell Responses and Immunotherapy of Cancer / George J. Weiner -- Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay / Eli Gilboa -- Employing T Cell Homeostasis as an Antitumor Strategy / Shawn M. Jensen, Christopher C. Paustain and Bernard A. Fox -- Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor / Dinorah Friedmann-Morvinski, Tova Waks, Assaf Marcus and Zelig Eshhar -- Part II: Evolving Clinical Immunotherapeutic Strategies -- Immunotherapy in Renal Cell Carcinoma / Jennifer Cudris and Jaime R. Merchan -- Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies / Aaron P. Rapoport and Nadia Ijaz -- Bifunctional Antibodies: Preclinical and Clinical Applications / Casey W. Shuptrine and Louis M. Weiner -- Clinical Development of Antibody-Fusion Proteins for Cancer Therapy / Kory L. Alderson, Amy K. Erbe, Margaret Boyden and Paul M. Sondel -- Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy / Lazaros J. Lekakis and Krishna V. Komanduri -- The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities / Paolo Serafini and Donald T. Weed -- T Cell Co-regulatory Signals and Their Role in Cancer Therapy / Eitan R. Friedman, Lynn Feun, Pasquale Benedetto and Joseph D. Rosenblatt -- Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints / Theresa L. Whiteside
Summary Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Tumors -- Immunological aspects.
Cancer -- Immunological aspects.
Antigens, Neoplasm -- immunology
Neoplasms -- therapy
T-Lymphocytes, Cytotoxic -- immunology
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
MEDICAL -- Forensic Medicine.
MEDICAL -- Preventive Medicine.
MEDICAL -- Public Health.
Cancer -- Immunological aspects
Tumors -- Immunological aspects
Form Electronic book
Author Rosenblatt, Joseph D
ISBN 9781461488095