Front Matter; Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions; Mechanisms of Tumor-Associated T-Cell Tolerance; Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer; Regulatory T Cells in Cancer; Cancer-Induced Signaling Defects in Antitumor T Cells; Immunobiology of Dendritic Cells in Cancer; Macrophages and Tumor Development; Myeloid-Derived Suppressor Cells in Cancer; Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance
Summary
There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-pres
