Front Matter; Five Years of Increasing Structural Biology Throughput -- A Retrospective Analysis; Protein Production for Structural Genomics -- Strategies for the Next Phase; Introduction to Fragment Screening; Fragment-Based NMR Screening in Lead Discovery; Fragment-Based Screening by X-ray Crystallography; Scaffold-Based Drug Discovery; Biophysical Methods; Illustration of Current Challenges in Molecular Docking; Scoring Functions; Back Matter
Summary
Describes the developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions
