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Title Molecular and cellular methods in developmental toxicology / edited by George P. Daston
Published Boca Raton : CRC Press, ©1997


Description 1 online resource (284 pages) : illustrations
Series CRC Press methods in toxicology
CRC Press methods in the life sciences. Methods in toxicology.
Contents Molecular techniques for developmental toxicology : an introduction / George P. Daston -- Visualization of gene expression patterns by in situ hybridization / Urs Albrecht, Gregor Eichele, Jill A. Helms, and Hui-Chen Lu -- Utilizing transgenic mice to study gene regulation and function / Michael R. Blackburn and Rodney E. Kellems -- Use of antisense oligonucleotide technology and mouse whole-embryo culture to study gene function during organogenesis / Linda F. Potts and T.W. Sadler -- Nucleic acid amplification technologies / Richard h. Finnell, Scott J. Vacha, and Scott A. Mackler -- Fundamentals of protein identification : biochemical and immunological analysis of developmentally altered protein expression / Gerald B. Grunwald -- Immunohistochemistry / Philip E. Mirkes and Sally A. Little -- Cellular techniques for teratological cell death / Thomas B. Knudsen -- Applications of flow cytometry in developmental and reproductive toxicolgy / Kenneth H. Elstein and Robert M. Zucker -- Modern techniques for cell labeling in avian and murine embryos / Diana K. Darnell and Gary C. Schoenwolf
Summary This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Developmental toxicology -- Methodology
Molecular toxicology -- Methodology
Cytology -- Methodology
Fetus -- drug effects
Pregnancy -- drug effects
Cell Biology
Molecular Biology
MEDICAL -- Gynecology & Obstetrics.
MEDICAL -- Toxicology.
SCIENCE -- Life Sciences -- Biology -- Molecular Biology.
SCIENCE -- Life Sciences -- Biology -- Developmental Biology.
Cytology -- Methodology
Developmental toxicology -- Methodology
Molecular toxicology -- Methodology
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Daston, George P.
ISBN 9780429187193