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Title Teratogenicity testing : methods and protocols / edited by Luís Félix
Published New York : Humana Press : Springer, [2018]


Description 1 online resource (xv, 614 pages) : illustrations (some color)
Series Methods in molecular biology, 1940-6029 ; 1797
Methods in molecular biology (Clifton, N.J.) ; v. 1797. 1064-3745
Contents Overview of teratology / Ana M. Calado and Maria dos Anjos Pires -- Teratology study guidelines : an overview / Sofia Alves-Pimenta, Luís Félix, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio -- Biological concerns on the selection of animal models for teratogenic testing / Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio -- Validated embryonic stemcell test with murine embryonic stem cells / Lauren M. Walker, Darcie L.V. McClelland-Descalzo, and Nicole I. zur Nieden -- Human pluripotent stem cells to assess developmental toxicity in the osteogenic lineage / Joseph V. Madrid, Steven R. Sera, Nicole R.L. Sparks, and Nicole I. zur Nieden -- Chick embryonic cardiomyocyte micromass system for assessing developmental cardiotoxicity of drugs / Wasay Mohiuddin Shaikh Qureshi and Margaret K. Pratten -- Flow cytometry to evaluate potential developmental toxicants in the embryonic stem cell / Valéria Maria Lara, Kelly C. Santos Roballo, André Tadeu Gotardo, and Carlos Eduardo Ambrósio -- Morphology-based whole embryo culture for developmental toxicity of drugs / Bo Liang and Chi Chiu Wang -- Western blot methodologies for analysis of in vitro protein expression induced by teratogenic agents / Carlos Martins-Gomes and Amélia M. Silva -- Manipulation of microRNAs in cultured mouse embryos : applications for developmental toxicology / Fuqiang Yuan and Shao-yu Chen -- Insights into the phenotypic and behavioral effects of teratogenic drugs in Caenorhabditis elegans / Caralina Marín de Evsikova -- Effect of teratogens on development of Drosophila melanogaster / Dong Li and Xiaolin Bi -- Cellular responses in Drosophila melanogaster following teratogen exposure / Matheus C. Bianchini, José L.R. Portela, Robson L. Puntel, and Daiana S. Ávila -- Behavioral teratogenesis in Drosophila melanogaster / Monalisa Mishra and Bedanta Kumar Barik -- Evaluation of teratogenicity of pharmaceuticals using FETAX / Hariz Islas-Flores, Itzayana Pérez-Alvaréz, and Leobardo M. Gómez-Oliván -- Histological observation of teratogenic phenotypes induced in frog embryo assays / Mark E. Pownall and Margaret S. Saha -- Visualization of gene expression patterns by in situ hybridization on early stages of development of Xenopus laevis / Heithem M. El-Hodiri and Lisa E. Kelly -- Analysis of lethality and malformations during zebrafish (Danio rerio) development / Azhwar Raghunath and Ekambaram Perumal -- General whole-mount immunohistochemistry of zebrafish (Danio rerio) embryos and larvae protocol / Dércia Santos, Sandra M. Monteiro, and Ana Luzio -- Geometric morphometrics as a tool to evaluate teratogenic effects in Zebrafish (Danio rerio) / Kathryn E. Perez and Tisha C. King-Heiden -- Live metabolic profile analysis of zebrafish embryos using a seahorse XF 24 extracellular flux analyzer / Simon T. Bond, Kevin A. McEwen, Prusothman Yoganantharajah, and Yann Gibert -- Behavioral profiling of zebrafish (Danio rerio) larvae following teratogen exposure / Ana M. Valentim -- Omics in zebrafish teratogenesis / Benjamin Piña, Laia Navarro, Carlos Barata, Demetrio Raldúa, Rubén Martínez, and Marta Casado -- Proteomic analysis of zebrafish (Danio rerio) after chemical exposure / Yew Mun Lee, Caixia Li, Siew Hong Lam, Zhiyuan Gong, and Qingsong Lin -- Immunohistochemical assessment as a tool for investigating developmental toxicity in zebrafish (Danio rerio) / Carla Santos and Maria de Lurdes Pinto -- Oxidative stress assessment in zebrafish larvae / Inês Domingues and Carlos Gravato -- Hemodynamic studies for analyzing the teratogenic effects of drugs in the aebrafish embryo / Huseyin C. Yalcin -- Western blot analysis and immunostaining for prediction of embryotoxicity in Mus musculus / Yulia Irnidayanti, Win Darmanto, and Dias R. Sutiono -- Histological and histochemical profile for teratological assessment in Mus musculus / Maria de Lurdes Pinto and Paula Rodrigues -- In vivo analysis of apoptosis in embryonic hippocampus / Ahmad Salimi and Jalal Pourahmad -- Measurement of mitochondrial toxicity parameters in embryonic hippocampus / Ahmad Salimi and Jalal Pourahmad -- Animal tests for evaluation of cognitive impairment in neonatal mouse / Ahmad Salimi and Jalal Pourahmad -- Methodology of genotoxic and teratogenic studies in rats / Eyyup Rencuzogullari and Muhsin Aydin -- Whole mount in situ hybridization and morphometric analysis in rabbit embryos / Yoshinori Kawamura and Kiyoshi Matsumoto -- Glossary of key terms for teratology / Maria dos Anjos Pires and Ana M. Calado
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerProtocol viewed June 13, 2018)
Subject Teratogenicity testing -- Laboratory manuals
Teratogenic agents.
Abnormalities, Drug-Induced
Embryonic Development -- drug effects
Toxicity Tests
Medical -- Pharmacology.
Teratogenic agents
Teratogenicity testing
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Felix, Luis, editor
ISBN 9781493978830